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Cardiovascular disease is one of the risk factors affecting human health worldwide with increasing morbidity and mortality. The pathogenesis of heart disease is multifactorial and common causes of heart disease mainly consist of arterial hypertension, obesity, diabetes mellitus, renal dysfunction and inflammation. It is difficult to select a suitable model to investigate co-existing risk factors for certain cardiovascular disease.
Over the last few decades, surgical models, especially in rodents, have been widely used in the study of the pathomechanisms of cardiovascular disease due to their short breeding cycles and low housing costs. In addition, surgical techniques combined with genetic modifications and pharmacological approaches constitute a relatively comprehensive animal model.
Surgical models mainly include transverse aortic constriction (TAC) model, ascending aortic constriction model, pulmonary artery constriction model, Left coronary artery ligation model, etc. Creative Bioarray specializes in providing customized pharmacodynamic research services to help customers assess the efficacy of drug candidates and study the associated pathological mechanisms through different surgical models.
Creative Bioarray provides you with surgical models including but not limitted to:
With extensive experience in the field of cardiovascular disease, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Figure. 1. Evaluation of cardiac function in three groups of mice. a M-mode echocardiography showed increased left ventricular posterior wall thickness (LVPW) in TAC mice while APNtreated mice demonstrated reduced LVPW. b Mitral inflow pattern and c mitral annular velocity of TAC group revealed progressive diastolic dysfunction while APN-treated mice showed recovery of diastolic dysfunction.
Figure. 2. Evaluation of cardiac structure, and morphology in three groups of mice. d Representative global heart photographs. e Hematoxylin and eosin-stained LV transverse sections (original magnification × 400; sale bar, 20 μm). f Representative microscopic images of Masson's trichrome staining (original magnification × 400; sale bar, 75 μm).
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Han X, et al. Effects of Adiponectin on Diastolic Function in Mice Underwent Transverse Aorta Constriction[J]. Journal of Cardiovascular Translational Research, 2019:1-13.
Cardiovascular Disease Models: