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Murine cells show frequent spontaneous immortalization in contrust to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway.
Creative Bioarray can provide you immortalized murine cell lines with an integrated platform for meeting the needs for virtually any relevant research project.
Description: Rat brain microvascular endothelial cells were isolated and transfected with SV40LT...
Description: Mouse lung fibroblasts were isolated and transfected with SV40LT expressing lentiviral...
Description: Mouse Epididymal Adipose-derived Mesenchymal Stem Cells were transfected with SV40LT...
Description: Mouse Glomerular Mesangial cells were transfected with SV40LT expressing lentiviral...
Description: Mouse Pancreatic Stellate Cells were transfected with SV40LT expressing lentiviral...
Description: Immortalized Mouse Corneal Epithelial Cells from Creative Bioarray were developed...
Description: Immortalized Mouse Adipose-Derived Mesenchymal Stem Cells-SV40 from Creative Bioarray...
Description: Immortalized Mouse Granulosa Cells-SV40 were developed from mouse tissues transduced...
Description: Immortalized Mouse Pulmonary Artery Smooth Muscle Cells-SV40 were developed from...
Description: Immortalized Mouse Bone Marrow Mesenchymal Stem Cells-SV40 were developed from mouse...
Description: Immortalized Rat Hair Follicle Stem Cells-SV40 were developed from rat tissues transduced...
Description: Immortalized Rat Endothelial Progenitor Cells -SV40 were developed from rat tissues...
Description: Follicle stimulating hormone (FSH) receptor, a receptor uniquely expressed in ovarian...
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Description: The Immortalized Mouse Retinal Pigmented Epithelial Cells- HPV E6/E7, derived from...
