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Nonalcoholic Fatty Liver Disease Model

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Nonalcoholic fatty liver disease (NAFLD) is characterized by evidence of hepatic steatosis and associates with obesity, diabetes, insulin resistance etc. The spectrum of nonalcoholic fatty liver disease ranges from simple steatosis to nonalcoholic steatohepatitis (NASH). Nonalcoholic steatohepatitis is characterized by inflammation and may progress to fibrosis, resulting in cirrhosis and hepatocellular carcinoma. In recent years, the incidence of NAFLD has increased significantly, which caused a severe economic burden worldwide.

Creative Bioarray has many years of experience in the field of NAFLD and provides pharmacodynamic services for customers to help them assess the efficacy of compounds and study the associated pathological mechanisms through NAFLD model.

Nonalcoholic fatty liver disease models include but not limited to:

  • Dietary Models
    • Methionine and Aholine Deficient (MCD) Diet-induced NAFLD Model
    • Choline-Deficient L-Amino Acid-defined Diet-induced NAFLD Model
    • High-Fat Diet-induced NAFLD Model
  • Chemical-induced NAFLD Model
    • Carbon Tetrachloride-induced NAFLD Model
  • Transgenic Models
    • Lepob/Lepob (ob/ob) Mice Model

Species available

  • Rat
  • Mouse

Our capabilities

  • We evaluate the effect of compounds on liver parenchyma from rat/mice by H&E staining.

Assays available

  • Body weight detection
  • Pathological evaluation of liver
  • Steatosis assay

With extensive experience in the field of NAFLD, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.

Study examples

Effect of electrolyzed-alkaline water on body weight and composition. A: Body weight (n = 12, mean ± SD) c shows significant diference between high-fat and regular diets; B and C: Ventral view of dissected mice after 12 wk of the experiment. Black arrow: Retroperitoneal fat pads; white arrow epididymal fat pad. Insert: Fresh dissected liver. RW: Regular water; EAW: Electrolysed alkaline water; RD: Regular diet; HFD: High fat diet.Figure. 1. Effect of electrolyzed-alkaline water on body weight and composition. A: Body weight (n = 12, mean ± SD) c shows significant diference between high-fat and regular diets; B and C: Ventral view of dissected mice after 12 wk of the experiment. Black arrow: Retroperitoneal fat pads; white arrow epididymal fat pad. Insert: Fresh dissected liver. RW: Regular water; EAW: Electrolysed alkaline water; RD: Regular diet; HFD: High fat diet.

Diosgenin ameliorates the hepatic lipid accumulation in high-fat diet-fed rats. (A) Hematoxylin and eosin (H&E) and Oil red O staining of the rat liver.Figure. 2. Diosgenin ameliorates the hepatic lipid accumulation in high-fat diet-fed rats. (A) Hematoxylin and eosin (H&E) and Oil red O staining of the rat liver.

Quotation and ordering

If you have any special needs or questions regarding our services, please feel free to contact us at 631-626-9181 or . We look forward to cooperating with you in the future.

References

  1. Jackson, Karen, et al. "Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model." World journal of gastroenterology 24.45 (2018): 5095.
  2. Cheng, Silu, et al. "Diosgenin prevents high-fat diet-induced rat non-alcoholic fatty liver disease through the AMPK and LXR signaling pathways." international journal of molecular medicine 41.2 (2018): 1089-1095.

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CONTACT US USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
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Europe
Tel: 44-208-144-6005
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