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Thyroid Tumor Cells

Thyroid tumors encompass a wide spectrum of malignancies, from well-differentiated follicular and papillary carcinomas to aggressive anaplastic and medullary types. These tumors are characterized by distinct genetic alterations and varying degrees of cellular differentiation, posing significant challenges for both diagnosis and treatment.

Our thyroid tumor cell line collection offers a diverse and authentic set of in vitro models derived directly from human patient specimens. These models reflect the biological complexity and heterogeneity of thyroid cancers, providing essential tools for investigating tumor progression, exploring targeted therapeutic strategies, and studying mechanisms of treatment resistance.

Authentic Genetically Diverse Clinically Relevant Rigorously Tested

Thyroid tumor cell lines collection
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Key Features & Expertise

Our thyroid tumor cell lines stand out for the following features

Diverse Representation of Thyroid Cancers
  • Covers a broad range of thyroid malignancies, including follicular, papillary, and anaplastic subtypes
  • Includes models derived from primary tumors, lymph node metastases, and pleural effusions
  • Represents various patient demographics and clinical presentations
Deep Characterization & Reliable Performance
  • Genomic and phenotypic profiling available for key alterations
  • Documented growth characteristics suitable for reproducible in vitro studies
  • Consistent behavior across passages for reliable experimental outcomes
Quality You Can Trust
  • STR-authenticated to ensure cell line identity and purity
  • Mycoplasma-free and routinely screened for contamination
  • Stable supply with comprehensive technical support

FAQ

What types of thyroid cancer are represented in your cell line collection?

Our collection includes models derived from various thyroid cancer subtypes. For example, we offer lines originating from well-differentiated follicular carcinomas, such as FTC-133 and FTC-238, as well as papillary thyroid carcinomas like K1 and IHH-4. We also provide models of more aggressive forms, including anaplastic thyroid carcinomas such as 8505C and HTh83, and medullary variants like TT.

How do I choose the right thyroid cancer cell line for my research?

Selection should be based on your specific research focus. Consider the following factors:
  • Tumor subtype and differentiation status (e.g., follicular vs. anaplastic)
  • Genetic background and known mutations
  • Growth behavior and culture requirements
  • Whether you need a model for drug screening, metastasis studies, or mechanistic research

Are your thyroid tumor cell lines authenticated?

Yes. All cell lines are STR-authenticated to confirm their identity and are routinely tested to ensure they are mycoplasma-free. This helps minimize variability and ensures more reliable experimental results.

Can these cell lines be used for drug screening and resistance studies?

Absolutely. These cell lines are widely used in drug screening workflows, including high-throughput assays. Some models, such as ML-1 and TMH-1, are particularly noted for their multidrug resistance profiles, making them valuable for studying therapy resistance mechanisms.

How stable are thyroid tumor cell lines during long-term culture?

Like all cell lines, thyroid tumor models can exhibit phenotypic drift over time with continuous passaging. To maintain consistency, we recommend working with low-passage cells and following established cell banking practices.

Do you provide information on the source and history of each cell line?

Yes, for each cell line in our collection, we provide detailed information on its origin, including patient age, gender, tumor type, and isolation site. For instance, B-CPAP was established from a 76-year-old woman with metastasizing papillary thyroid carcinoma, while S-117 was derived from a 47-year-old woman in 1985.

How are the cell lines shipped and stored?

Cell lines are shipped either on dry ice or as cryopreserved vials. Once received, they should be transferred to liquid nitrogen for long-term storage to maintain viability and genetic integrity.
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For research use only. Not for any other purpose.