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Disease Models

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Efficacy studies of lead candidates in animal disease models are vital for preclinical candidate selection in drug discovery. The relevant disease models and DMPK assays are used to study the biological effects of drug candidates. Creative Bioarray has established multiple animal disease models including cardiovascular disease models, chronic liver disease models, metabolic disease models, neurological disease models, oncology models, etc. We provide validated and custom in vivo disease modeling and services. Our comprehensive animal-based disease models of different organ systems allow our clients to choose the most appropriate models to test promising compounds and optimize lead candidates.

Disease Models

Available in vivo disease models:

Surgical Models

  • Cisterna magna cannulation
  • Bile duct cannulation
  • Portal vein cannulation
  • Thoracic duct cannulation
  • Intraduodenally administration

Inflammation & Autoimmune Disease Models

  • Arthritis
  • Imiquimod (IMQ) induced-psoriasis
  • Dextran Sulfate Sodium (DSS) -induced colitis
  • Immune disease (CIA, DTH, PCA, EAE)
  • Non-Immune inflammatory
  • Compound 48/80-induced scratching behavior
  • Peripheral neuroinflammation

Acute and Chronic Pain Models

  • Visceral pain
  • Surgery pain
  • Neuropathic pain
  • Bone cancer pain
  • Chronic joint pain
  • Acute tonic pain
  • Acute inflammatory pain
  • Neuropathic pain
  • Nociceptive pain

Cardiovascular Disease Models

  • Atherosclerosis
  • Carotid artery ligation
  • Hypertension
  • Restenosis following carotid balloon angioplasty
  • Chemically-induced carotid thrombus formation
  • Thrombosis
  • Middle cerebral artery occlusion (MCAO)
  • Spontaneously hypertensive (SHR)
  • Cardiac ischemia / reperfusion
  • Hyperlipidemia

Chronic Liver Disease Models

  • Liver fibrosis / cirrhosis (CCI4, TAA, DMNA and BDL)

Metabolic Disease Models

  • Obesity
  • Type 1 Diabetes
  • Type 2 Diabetes (NAFLD & NASH)
  • Organ damage (UUO, CKD)

Neurological Disease Models

  • Alzheimer’s disease
  • Hot-water immersion tail-flick test
  • Memory impairment
  • Sciatic nerve chronic constriction
  • Seizure
  • Acetic acid-induced writhing test
  • Formalin test
  • Spinal cord injury (SCI)
  • Primary dysmenorrhea
  • Parkinson’s disease and other neurodegenerative

Ocular Disease Models

  • Inflammatory disorders
  • Eye irritation
  • Retinopathy of prematury
  • Stromal ulceration
  • Corneal graft
  • Infectious keratitis
  • Diabetic retinopathy

Oncology Models

  • Cell line-derived xenograft models (CDX)
  • Patient-derived xenograft models (PDX)
  • Syngeneic and orthotopic imaging

Rare Disease Models

  • Huntington's disease
  • Amyotrophic lateral sclerosis (ALS)
  • Batten disease
  • Multiple sclerosis (MS)
  • Systemic lupus erythematosus (SLE)
  • Muscular dystrophy

Respiratory Disease Models

  • Chronic obstructive pulmonary disease (COPD)
  • Acute Lung
  • Injury
  • Ammonia-induced cough
  • Allergic rhinitis
  • LPS-induced acute lung injury model
  • Idiopathic pulmonary fibrosis
  • Acute or Chronic cough
  • Asthma
  • Pulmonary infection
  • Lung fibrosis
  • Preparation of guinea pig airway smooth muscle
  • Lung inflammation model
  • Hyperuricemia

Urology Disease Models

  • Cisplatin-induced nephrotoxicity
  • Unilateral ureteral obstruction (UUO)
  • 5/6 Nephrectomy

Disease Models

Each of the above disease models is designed to understand specific aspects of drug property and its mechanism of action. Besides, the animals used for studies are provided by certified animal suppliers. All study protocols and animal use are approved by IACUC. By accessing our comprehensive capability, our customers can advance their drug discovery projects faster.

Contact us for more information on the listed disease models or if you would like to customize a new model to meet your particular needs. With all our In Vivo Services, we ensure continuous communications and discussions during on-going studies. Please feel free to contact us at or 1-631-626-9181 to find out more about our capabilities and services.


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CONTACT US USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
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