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Alcoholic Liver Disease Model

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Alcohol consumption, both acute and chronic, is an important health and economic concern worldwide. So far, alcohol abuse has become the fifth leading global cause of preventable morbidity and mortality. Excessive alcohol intake is one of the risk factor for the development of multi-organ pathology, including alcoholic liver disease (ALD).

Alcoholic Liver Disease (ALD) is identified as a spectrum of clinical disorders, which consists of fatty liver, alcoholic hepatitis (AH), cirrhosis and even hepatocellular carcinoma. It is reported that 95 percent of heavy drinkers develop fatty liver. Therefore, it is necessary to develop suitable animal models for studying its pathogenesis and test new therapies.

Creative Bioarray focuses on drug research and development as well as helping customers evaluate the efficacy of drug candidates and study the pathological mechanisms through alcoholic liver disease model.

Animal models available

  • Lieber-DeCarli liquid diet induced ALD model
  • Tsukamoto–French model
  • Second-hit models
    • EtOH administration with a high fat diet
    • EtOH administration with lipopolysaccharide
  • Genetically modified models

Species available

  • Rat
  • Mouse

Our capabilities

  • We detect body weight of rodents at different time points.
  • Serum and liver ALT, AST, TG, TC, and LDL cholesterol concentrations were determined by colorimetric methods.
  • We analyze the hepatic histology by Hematoxylin and Eosin (H&E) and Oil-Red-O staining.
  • We detect associated protein expression and RNA level by Western blot, immunofluorescence staining and RT-qPCR, respectively.

Assays available

  • Biochemical analysis 
  • Pathological evaluation

With extensive experience in the field of ALD, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.

Study examples

Serum concentrations of ALT (A), AST (B), TGs (C), total cholesterol (D), and LDL cholesterol (E) in male mice fed a control diet or an ethanol-containing diet with or without luteolin for 2 wk.Figure. 1. Serum concentrations of ALT (A), AST (B), TGs (C), total cholesterol (D), and LDL cholesterol (E) in male mice fed a control diet or an ethanol-containing diet with or without luteolin for 2 wk.

Body weight of male mice that consumed a control diet or an ethanol-containing diet with or without luteolin for 2 wk.Figure. 2. Body weight of male mice that consumed a control diet or an ethanol-containing diet with or without luteolin for 2 wk.

Hematoxylin and eosin staining and Oil-Red-O stainingFigure. 3. Hematoxylin and eosin staining and Oil-Red-O staining

Quotation and ordering

If you have any special needs or questions regarding our services, please feel free to contact us at 631-626-9181 or . We look forward to cooperating with you in the future.

Reference

  1. Liu G , Zhang Y , Liu C , et al. Luteolin Alleviates Alcoholic Liver Disease Induced by Chronic and Binge Ethanol Feeding in Mice[J]. Journal of Nutrition, 2014, 144(7):1009-1015.


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CONTACT US USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
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Europe
Tel: 44-208-144-6005
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