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Creative Bioarray provides cell-based nephrotoxicity assays to test and identify renal toxic compounds. The kidney plays an important role in eliminating drug metabolites. Several drugs, particularly aminoglycosides, have manifested drug-induced nephrotoxicity. With a group of well experienced experts in the field of drug discovery, Creative Bioarray is able to assist you with study design, experiment conduct, and data analysis to evaluate the nephrotoxicity of your compounds at an early stage of drug discovery.
Nephrotoxicity, also referred to as renal toxicity, is one of the most common kidney problems which occurs when exposed to a drug or toxin that causes damage to the kidney. When kidney damage occurs, the body is unable to get rid of the excess urine and wastes that are usually removed through kidney. Nephrotoxicity can lead to acute Kidney injuries which is the rapid loss of kidney function and the precursor of acute renal failure, or chronic kidney disease which is a long process that may result in end-stage renal disease and require dialysis or kidney transplant. Therefore, screening drug candidates for nephrotoxicity is of great importance for ruling out renal toxic drugs and preventing such tragic incidents in the pre-clinical and clinical stage.
In order to better avoid late stage drug failure due to nephrotoxicity, Creative Bioarray offers the following assays using Human renal proximal tubule epithelial cells (HRPTEpiC) or Human renal epithelial cells (HREpC) to test drug candidates for renal toxicity.
Mitochondrial Stress Assessment
Creative Bioarray is able to carry out multiplexed nephrotoxicity assays based on human renal epithelial cells. Our experts are capable of designing customized assays to meet the requirements of our clients. Please feel free to contact us to learn more about the assays and our capabilities in drug toxicity screening. We will try our best to assist you to achieve your goal.
Cell-Based Drug Discovery:
In Vitro Nephrotoxicity: