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iPSC Differentiation

Differentiation is the process where an unspecialized cell acquires cellular traits that allow it to perform specialized functions. Indeed, the actual potential of iPSCs rest in their direct differentiation to various types of somatic cells. In order to use iPSCs to treat disease or as research tools to study diseases, fully functioning specialized cells are required for testing potential drugs or transplanting healthy cells in clinical stages. Creative Bioarray has developed protocols for iPSC differentiation to various lineage-committed cell types thereby expanding the scope of your research, drug discovery, or screening projects.

iPSC Differentiation

Creative Bioarray Offers iPSC Differentiation Service for Your Scientific Research as Follows (including but not limited to):

  • Neuronal cells from iPSCs

The process of iPSC differentiation to neurons and neuronal cells is of special importance for neurobiology and related disorders, considering the dearth of clinically relevant in vitro models available for research, drug screening and development. Creative Bioarray now focuses on directing hiPSCs into four major specific neuronal sublineages which are serotonergic, cholinergic/motor, dopaminergic, and serotonergic neurons.

Neural cells, such as: Neural stem cells (NSCs), Neural Progenitor cells (NPCs), Mature Astrocytes, Dopaminergic neurons, Motor neurons progenitor, Cerebral cortical neurons, Oligodendrocytes, DOPA Neuron, Microglia.

  • Retinal pigment epithelium (RPE) from iPSCs

Human iPSC-derived retinal pigment epithelium (RPE) provides a physiologically functional cell model to study ocular diseases. Creative Bioarray provides high quality RPE with typical cobblestone morphology and pigmentation, and high purity RPE expressing RPE-specific markers BEST1/rpe65.

  • Cardiomyocytes from iPSCs

Creative Bioarray offers ready-to-use and functional cardiomyocytes that are desirable in vitro models for high content toxicity and drug screening, and cell regeneration research. We provide iPSC-derived cardiomyocytes from healthy or diseased patients.

  • Hepatocytes from iPSCs

iPSC-derived hepatocytes as developing liver disease models, are feasible and physiologically relevant alternative for discovering therapeutic treatments, drug targets, and understanding drug induced liver inquiries (DILI). Creative Bioarray's hepatocyte differentiation services include: expansion of iPSCs, progenitor cells differentiation and characterization, terminal differentiation, and characterization of differentiated cells by ICC (per markers).

Example for neural stem cell (NSC) differentiation from iPSCs:

Generation and characterization of neural stem cells derived from iPSCs.Fig. 1 Generation and characterization of neural stem cells derived from iPSCs.

Creative Bioarray is an experienced and outstanding provider of iPSC differentiation service. We are dedicated to providing quality data and comprehensive service for your scientific research, and we are pleased to use our extensive experience and advanced platform to offer the best service to satisfy each demand from our customers.

If you have any special need in iPSC differentiation service, do not hesitate to contact us at or 1-631-626-9181 for this special service. Please let us know what you need and we will accommodate you. We are looking forward to working with you in the future.

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References

  1. Xu, Maojia, et al. "Induced Pluripotent Stem Cell‐Derived Mesenchymal Stromal Cells Are Functionally and Genetically Different From Bone Marrow Derived‐Mesenchymal Stromal Cells." Stem Cells (2019).
  2. Baksh, D., et al. "Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy." Journal of cellular and molecular medicine 8.3 (2004): 301-316.

For research use only. Not for any other purpose.


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