Monosodium Iodoacetate (MIA)-Induced Osteoarthritis (OA) Model

Creative Bioarray provides a monosodium iodoacetate (MIA)-induced osteoarthritis (OA) model for our clients to study the disease mechanisms or evaluate the efficacy of drug candidates. With our services, you can obtain reliable and accurate results, providing valuable insights into drug development.

OA is the most common form of arthritis among middle-aged and elderly individuals. Its etiology is complex and involves multiple factors, with the underlying pathogenic mechanisms remaining elusive. While the progression of the disease is typically slow, it can result in significant pain and disability, negatively impacting the quality of life. Given the challenges in studying OA in humans, animal models have become crucial in assessing the development of the disease and evaluating innovative treatment strategies.

Currently, the most utilized type of chemical induction is MIA, which has an inhibitory activity of glyceraldehyde-3-phosphate dehydrogenase glycolysis and induces the death of chondrocytes. In both rodents and non-rodents, the intra-articular injection causes chondrocyte destruction. When administered in rats, it causes cartilage lesions with loss of proteoglycan matrix and functional alterations with stiffness that are analogous to those seen in human osteoarthritis.

Our Monosodium Iodoacetate (MIA)-Induced Osteoarthritis (OA) Model

• Available Animal
  Rat
• Modeling Method
  After anesthetization, rats are given a single intra-articular injection of MIA through the infrapatellar ligament of the right knee.
• Endpoints
  • Behavioral test
  • Histology analysis (knee joint): H&E staining, Safranin-O/Fast Green staining
  • Mankin score
  • Serum analysis: cytokine, SOD, MDA, etc.
  • Body weight
  • Other customized endpoints

Example Data

Fig. 1 Histopathological features of knee joint tissues in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) rats. Knee joint tissues histopathological changes with (A) H&E and (B) Safranin-O/Fast Green

Meanwhile, we also provide other OA models that maybe you are interested in:

• Papain-Induced Osteoarthritis (OA) Model
• Medial Meniscal Tear (MMT)-Induced Osteoarthritis (OA) Model
• Anterior Cruciate Ligament Transection (ACLT)-Induced Osteoarthritis (OA) Model

Quotation and Ordering

With years of experience in disease models, the scientists at Creative Bioarray are eager to collaborate with our clients to create a customized design tailored to your unique needs. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.

References

1. Lee, Y.M., et al. Anti-inflammatory and analgesic effects of Schisandra chinensis leaf extracts and monosodium iodoacetate-induced osteoarthritis in rats and acetic acid-induced writhing in mice. Nutrients, 2022, 14(7): 1356.
2. Longo, U.G., et al. Induced models of osteoarthritis in animal models: a systematic review. Biology, 2023, 12(2): 283.