Unilateral Ureteral Obstruction Model

The Unilateral Ureteral Obstruction (UUO) model is widely used to induce acute kidney injury, where the primary feature of UUO is tubular injury as a result of obstructed urine flow. The experimental procedure involves ligation of the ureter, usually with a silk thread, most commonly of the left one. The kidney of the ligated ureter is termed the "Obstructed Kidney". Creative Bioarray provides you the UUO model for studying the mechanism of acute kidney injury and developing related therapeutic drugs.

Application and advantages

The UUO model has been used by some researchers and shows significant research potential. With this model, you can apply your research to the following aspects:

  • Explore the resolution of kidney inflammation together with key aspects of tissue repair.
  • Reveal useful biomarkers of progression of renal disease and new therapies.
  • Study the pathogenesis of renal fibrosis and drug intervention.

Besides, it is one of the most common models of urology disease. The reason is that it is easily induced in rodents, with high reproducibility and a short timeline. This makes it successfully applied in the above aspects.

Related Assays provided by Creative Bioarray including

  • Clinical observations
  • Microalbumin test
  • Biochemical analysis
  • RT-PCR & western blot
  • Histology & immunohistochemistry

Data & Figures

(A) Representative H&E staining of kidney sections under 50× and 200× magnification. (B) Tubulointerstitial injury score of the four groups.Figure 1. (A) Representative H&E staining of kidney sections under 50× and 200× magnification. (B) Tubulointerstitial injury score of the four groups.

Other urological disease models are also available:

Quotation and ordering

For more details, please do not hesitate to contact us.

Reference

  1. Gu L et al. Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-beta signaling pathways in mice. J. Ethnopharmacol., 2018, 231:302-310.

For research use only. Not for any other purpose.