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A better understanding of the wound healing process leads to generating better products that aid in healing hard-to-heal wounds such as chronic wounds. Cell migration during the wound healing process is an important step of a complete healing. In vivo, the wound healing process includes different cell types (macrophages, fibroblasts, and keratinocytes) coming in and out of the wound bed at different time points. Mimicking the in vivo milieu with an in vitro 3D model will assist wound healing scientists to better understand the wound healing or re-epithelialization process and aid companies in generating better products of helping with hard-to-heal acute wounds and chronic wounds.
Creative Bioarray provides in vitro 3D skin tissue models and evaluation assays to support cosmetic or dermatological industries in generating products of helping with wound healing or re-epithelialization.
In vitro 3D skin models available
Screening assays available
Fig1. Increased basal keratinocyte proliferation in 3D FTSK model. Representative images of tissue sections stained for BrdU incorporation are shown (arrowheads mark examples of BrdU-stained nuclei, and arrows mark examples of BrdU-negative nuclei). Quantification of mean percentage of basal keratinocytes positive for BrdU±SD. FTSK, full thickness skin model.
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In vitro Skin Models: