Nasopharyngeal Tumor Cells
Nasopharyngeal Carcinoma (NPC) is a unique epithelial malignancy with a distinct geographical distribution, showing high prevalence in Southern China and Southeast Asia. Its pathogenesis is closely linked to Epstein-Barr virus (EBV) infection, genetic susceptibility, and environmental factors.
Our nasopharyngeal tumor cell line collection offers a diverse range of models, including differentiated and undifferentiated non-keratinizing carcinoma types. These cell lines serve as critical tools for investigating viral oncogenesis, understanding the mechanisms of high metastatic potential, and screening for novel radiosensitizers and immunotherapeutic agents.
EBV-Related Highly Characterized Metastatic Models Quality Assured
Key Features & Expertise
Our nasopharyngeal tumor cell lines are meticulously validated to provide high-performance models for head and neck oncology research:
Comprehensive Histological Range
- Models covering keratinizing squamous cell carcinoma (WHO type I) and non-keratinizing (WHO type II/III).
- Includes cell lines derived from primary sites and metastatic lymph nodes.
- Diverse differentiation states reflecting the clinical heterogeneity of NPC.
Viral & Molecular Profiling
- Ideal platforms for studying EBV latency and viral oncoproteins like LMP1 and EBNA1.
- Documented genetic alterations, including characteristic 1p, 3p, and 9p deletions.
- Verified signaling pathways status, including NF-κB, PI3K/AKT, and Wnt/β-catenin.
Research-Ready Reliability
- STR authenticated to ensure cell identity and prevent cross-contamination (e.g., HeLa contamination).
- Certified Mycoplasma-free to ensure experimental reproducibility and data accuracy.
- Optimized for radiosensitivity studies, angiogenesis assays, and xenograft modeling.
FAQ
Do all nasopharyngeal carcinoma cell lines carry the EBV virus?
Not all NPC cell lines retain the EBV genome during long-term in vitro culture; some classic lines may lose the virus. We clearly state the EBV status for each line in our product list to help you select the most appropriate model.
Which cell lines are best for studying NPC metastasis?
Cell lines derived from metastatic sites or those characterized with a highly invasive phenotype are recommended. These models show strong migration capabilities in Transwell assays and in vivo models.
What are the recommended culture conditions for NPC cells?
Most NPC lines grow well in RPMI-1640 or DMEM supplemented with 10% FBS. We provide detailed culture protocols and specific media recommendations for each cell line to ensure optimal growth and phenotype maintenance.
Do you provide normal nasopharyngeal epithelial cell lines as controls?
Yes, we offer immortalized normal nasopharyngeal epithelial cells, which serve as ideal controls for studying early molecular changes and evaluating drug toxicity.
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Description: The Paclitaxel-resistant cell line WSU-HN30/Taxol has been developed by repeatedly exposing the ...
Description: Japanese maxillary simus squamous carcinoma.
Description: The Cisplatin-resistant cell line FADU/DDP has been developed by repeatedly exposing the parent ...