Our Promise to You

Guaranteed product quality, expert customer support

Our Promise to You

CABR™ CAR-T Cell Detection ISH Probes

What is CAR-T cell therapy? It is a type of treatment mainly about isolating the patient's T cells and genetically engineering the cells to express chimeric antigen receptors (CARs), which can recognize a specific tumor associated antigen, such as CD19, BCMA and CD20. After infusing the engineered CAR-T cells into the body, the tumor cells are targeted efficiently. Two landmark events occurred for CAR-T cell therapy in 2017: two anti-CD19 CAR-T cells were approved by FDA for the therapy of acute lymphoblastic leukemia (ALL) and relapsed or refractory large B-cell lymphoma, respectively. From then, increasing number of researchers have been dedicated to CAR-T cell therapy research around the world.

Toxicity Assessment of CAR-T Cells

"On-target/off-tumor" toxicity was an expected side effect of CAR T therapy from the outset. In Situ Hybridization (ISH) is a great method that can be utilized to identify novel CAR-T cell targets and subsequently qualify monoclonal antibodies directed against those targets for immunohistochemistry. ISH can be used to predict CAR-T cell target organ toxicity in preclinical models.

Disrtribution Assessment of CAR-T Cells

The distribution of CAR-T cells in the tumor and in the body is important for assessing the antitumor effect and safety of the injected CAR-T in vivo, while observing the antitumor effect. ISH can be used to evaluate the CAR expression.

Multifocal CAR cell infiltrates associated with increased expression of IFN-γ, CD25 and CD134 and tumor cell EGFRvIII expression. Post EGFRvIII-CAR treatment biopsies of glipbalstoma multiforme (6 days).Figure 1. Multifocal CAR cell infiltrates associated with increased expression of IFN-γ, CD25 and CD134 and tumor cell EGFRvIII expression. Post EGFRvIII-CAR treatment biopsies of glipbalstoma multiforme (6 days).

Creative Bioarray has successfully developed CAR-T Cell Detection ISH probes, covering most of the investigational CAR-T cell therapy targets. The probes with highest quality with bright, easy to interpret signals. Therefore, CAR-T cell target ISH probes in Creative Bioarray are the first choice for your project

See All CABR™CAR-T Cell Detection ISH Probe >>>

Associated MalignancyTarget AntigenCABR™ CAR-T Cell Detection ISH Probes
LeukemiaCD19Anti-CD19 CAR-T Cell ISH Probe
k-light chainAnti-k-light chain CAR-T Cell ISH Probe
CD33Anti-CD33 CAR-T Cell ISH Probe
CD123Anti-CD123 CAR-T Cell ISH Probe
WT1Anti-WT1 CAR-T Cell ISH Probe
Pr3Anti-Pr3 CAR-T Cell ISH Probe
LymphomaCD19Anti-CD19 CAR-T Cell ISH Probe
CD20Anti-CD20 CAR-T Cell ISH Probe
CD22Anti-CD22 CAR-T Cell ISH Probe
CD30Anti-CD30 CAR-T Cell ISH Probe
k-light chainAnti-k-light chain CAR-T Cell ISH Probe
Breast and otherserb-B2Anti-erb-B2 CAR-T Cell ISH Probe
erb-B2,3,4Anti-erb-B2,3,4 CAR-T Cell ISH Probe
MUC1Anti-MUC1 CAR-T Cell ISH Probe
LeYAnti-LeY CAR-T Cell ISH Probe
Prostate cancererb-B2Anti-erb-B2 CAR-T Cell ISH Probe
PSCAAnti-PSCA CAR-T Cell ISH Probe
Colorectal cancerEGP-40Anti-EGP-40 CAR-T Cell ISH Probe
erb-B2Anti-erb-B2 CAR-T Cell ISH Probe
Lung malignancyHer2/neuAnti-Her2/neu CAR-T Cell ISH Probe
AdenocarcinomasTAG-72Anti-TAG-72 CAR-T Cell ISH Probe
Cervical carcinomaCD44v7/8Anti-CD44v7/8 CAR-T Cell ISH Probe
MelanomaGD3Anti-GD3 CAR-T Cell ISH Probe
MAGE-A1Anti-MAGE-A1 CAR-T Cell ISH Probe
Renal cell carcinomaCAIXAnti-CAIX CAR-T Cell ISH Probe
Epithelial derived tumorsLeYAnti-LeY CAR-T Cell ISH Probe
Advanced osteosarcomaHer2/neuAnti-Her2/neu CAR-T Cell ISH Probe
RhabdomyosarcomaFetal acethylcholine receptorAnti-Fetal acethylcholine receptor CAR-T Cell ISH Probe
Ewing'sGD2Anti-GD2 CAR-T Cell ISH Probe
sarcomaNKG2DAnti-NKG2D CAR-T Cell ISH Probe
MUC1Anti-MUC1 CAR-T Cell ISH Probe
survivinAnti-survivin CAR-T Cell ISH Probe
CSPG4Anti-CSPG4 CAR-T Cell ISH Probe
MedulloblastomaHer2/neuAnti-Her2/neu CAR-T Cell ISH Probe
IL-13R-a2Anti-IL-13R-a2 CAR-T Cell ISH Probe
NeuroblastomaGD2Anti-GD2 CAR-T Cell ISH Probe
L1 cell adhesion moleculeAnti-L1 cell adhesion molecule CAR-T Cell ISH Probe
CD171Anti-CD171 CAR-T Cell ISH Probe
EGFRvIIIAnti-EGFRvIII CAR-T Cell ISH Probe
ROR1Anti-ROR1 CAR-T Cell ISH Probe
Ovarian cancerα-Folate receptorAnti-α-Folate receptor CAR-T Cell ISH Probe
FBPAnti-FBP CAR-T Cell ISH Probe
MUC1Anti-MUC1 CAR-T Cell ISH Probe
GliomaHer2/neuAnti-Her2/neu CAR-T Cell ISH Probe
IL-13R-a2Anti-IL-13R-a2 CAR-T Cell ISH Probe
Multiple malignanciesEGP-2Anti-EGP-2 CAR-T Cell ISH Probe
Various tumorsMesothelinAnti-Mesothelin CAR-T Cell ISH Probe
NKG2D ligandsAnti-NKG2D ligands CAR-T Cell ISH Probe
Tumor neovasculatureKDRAnti-KDR CAR-T Cell ISH Probe
Prostate/tumor vasculatureVEGF-R2Anti-VEGF-R2 CAR-T Cell ISH Probe
PSMAAnti-PSMA CAR-T Cell ISH Probe

For research use only. Not for any other purpose.