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Cardiac Cells

Cardiac system is responsible for pumping oxygen-enriched blood to organs, tissues and cells in the body, and removing carbon dioxide and waste. The system consists of endothelial cells, myocytes, smooth muscle cells and fibroblasts, which work together to maintain the function of the circulatory system. Abnormal cell proliferation and regulation in the cardiac system may lead to the development of cardiovascular diseases. Creative Bioarray can offer several types of human cardiac cells, which can be used in assays of adhesion, migration, angiogenesis, regenerative medicine, drug screening, and disease modeling.

Human Cardiac Fibroblasts

Cardiac fibroblasts (CF) are the most common cell type in the heart. CF play a central role in the maintenance of extracellular matrix in normal heart and the synthesis of growth factors and cytokines. Under pathophysiological conditions, CF are involved in cardiac hypertrophy, cardiac fibrosis and scar formation after cardiac infarction. Therefore, CF represent an attractive therapeutic candidate for heart disease. CF cultures have been widely used as a model to study the cardiac matrix remodeling by physiological (exercise) and pathological (hypertension) stressors.

Human Cardiac Myocytes

Cardiac myocytes are the most physically energetic cells in the human body. They are highly specialized cells with high oxygen content and house a large number of mitochondria. They account for as much as 75% of the heart by mass. All cardiac myocytes are capable of spontaneous rhythmic depolarization and repolarization of their membranes. The contraction of cardiac myocytes is myogenic, which is independent of nervous stimulation. There is a complex signal network in cardiac myocytes that regulates the heart's rhythmic pumping. A better understanding of the cardiac signaling network will help to reveal the cellular mechanisms regulating to cardiac myocyte death. The ideal cell type for most cardiac microphysiological systems is primary human adult cardiac myocytes, because they are fully differentiated and are expected to most closely mimic the adult human disease process and drug response.

Human Cardiac Microvascular Endothelial Cells

Human cardiac microvascular endothelial cells (HCMEC) intensively interact with cardiomyocytes and therefore have a characteristic phenotype different from other microvascular endothelial cells. HCMEC regulate vascular tone by releasing and degrading endothelium-derived vasoactive factors, and modulating the local levels of vasoconstrictors and vasodilators through their enzymatic activities. Many of these substances can also modify myocardial contractile behavior. In addition, the microvasculature has been shown to participate in the regulation of leukocyte recruitment, inflammation, and angiogenesis. They are also able to trans-differentiate into myofibroblasts, indicating a role in the abnormal accumulation of matrix and fibrotic disorders. The cultured HCMEC provide a valuable tool for understanding the physiological and pathophysiological correlation of HCMEC in cardiac function and disease.

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Description: HPcF from Creative Bioarray are isolated from the human heart. HPcF are cryopreserved...

Cat#: CSC-7739W INQUIRY

Description: HCF-fa from Creative Bioarray are isolated from the human fetal atrium. HCF-fa are...

Cat#: CSC-7815W INQUIRY

Description: HCFav from Creative Bioarray are isolated from the human heart. HCF-av are cryopreserved...

Cat#: CSC-7816W INQUIRY

Description: HCFaa from Creative Bioarray are isolated from the human heart. HCF-aa are cryopreserved...

Cat#: CSC-7817W INQUIRY

Description: HCF from Creative Bioarray Research Laboratories are isolated from the human heart...

Cat#: CSC-7818W INQUIRY

Description: HAAF from Creative Bioarray Research Laboratories are isolated from human aortic...

Cat#: CSC-7839W INQUIRY

Description: Human Cardiac Microvascular Endothelial Cells from Creative Bioarray are isolated...

Cat#: CSC-C1464 INQUIRY

Description: Human cardiac stromal cells are derived from whole hearts that have been dissociated...

Cat#: CSC-C2846 INQUIRY

Description: Cardiomyocytes are derived from the whole heart (of a single donor) that has been...

Cat#: CSC-C2847 INQUIRY

Description: Creative Bioarray has developed Human iPSC-Derived Cardiomyocytes, in addition to...

Cat#: CSC-C2847SC INQUIRY

Description: Cardiac progenitor cells are derived from the heart (of a single donor) that has...

Cat#: CSC-C3118 INQUIRY

Description: Human hypertension cardiac microvascular endothelial cells from Creative Bioarray...

Cat#: CSC-C4985J INQUIRY

Description: Human hypertension cardiac fibroblasts are isolated from the heart of human donor...

Cat#: CSC-C4997J INQUIRY

Description: Diseased human pulmonary artery cells and media are convenient and easy to use, allowing...

Cat#: CSC-C8100L INQUIRY

Description: Diseased human pulmonary artery cells and media are convenient and easy to use, allowing...

Cat#: CSC-C8101L INQUIRY

Description: Human Coronary Artery Endothelial Cells from Creative Bioarray are isolated from...

Cat#: CSC-C8595W INQUIRY

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