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Metabolic Disease Models

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With increasing incidence of metabolic diseases, these diseases have attracted wide attention in the medical field all over the world. It is estimated that about 20-25% of adults in the world suffer from metabolic diseases. Meanwhile, as a syndrome, metabolic diseases have no single cause.

The use of animals in experimentation was and continues to be of great importance in medical research. Animal models of metabolic diseases provide an opportunity to examine correlations among different metabolic parameters. Creative Bioarray provides professional drug testing services using these models.

Methods used to induce diseases in rodents include dietary manipulation, genetic modification, and drugs. Our pharmacology team developed a variety of metabolic disease models based on customer requirements to test the efficiency of drugs. Multiple species are available, such as non-human primates, dogs, mice and rats, rabbits and guinea pigs.

Our portfolio of metabolic disease models cover the following diseases

  • Obesity
  • Type 1 Diabetes
  • Type 2 Diabetes (NAFLD & NASH)
  • Organ damage (UUO, CKD)
  • Hyperuricemia
  • Dyslipidemia

We provide highly customizable services

  • Changing the light/dark cycle
  • Individualized sample collection
  • Biomarker analysis

assays of multiple cytokines, mRNA, histology and immunohistochemistry

Data & Figures

Metabolic Disease Models Figure1. OCA treatment improves hepatic ballooning in NASH models.

In addition, our professionals have the expertise and research equipment to study the interaction between microbiome and metabolic diseases, which attribute important new aspects to your drug development research.

Quotation and ordering

We have extensive experience in developing disease models based on scientific publications. To discuss any of these models further or to discuss the possibility of developing alternative models, please do not hesitate to contact us at or 1-631-626-9181.

Reference

  1. Wong, S. K., Chin, K.-Y., Suhaimi, F. H. Animal models of metabolic syndrome: a review. Nutr. Metab. 13, (2016).

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CONTACT US USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
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Europe
Tel: 44-207-097-1828
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