Probe Development & Quality Control
Quality control is an essential component of any cytogenetic and in situ hybridization experiment. Poorly designed FISH probes can lead to suboptimal target detection and variable signal intensity, resulting in poor reproducibility especially in clinical and regulated settings.
Our Probe Development & Quality Control services focus on the end-to-end engineering and validation of FISH probes, from rational sequence design and synthesis to functional testing and performance verification. Through standardized quality assessment workflows and rigorous batch-to-batch evaluation, we help researchers minimize experimental variability, improve signal specificity, and ensure long-term reliability of probe-based assays across diverse applications and sample types.
Our Services
FISH Probe Design, Synthesis and Testing Service
Offers customized design, synthesis, labeling, and rigorous functional validation services for Fluorescent In Situ Hybridization (FISH) probes.
Comprehensive evaluation of probe specificity, signal intensity, batch consistency, and overall hybridization performance.
Quality Control Parameters and Performance Standards
All FISH probes undergo systematic quality control to ensure reliable performance in downstream applications. Key evaluation parameters include:
Specificity Assessment
- Verification of target-specific hybridization and absence of off-target signals.
Signal Intensity and Signal-to-Noise Ratio
- Quantitative and qualitative evaluation of fluorescence signal clarity under standardized imaging conditions.
Batch-to-Batch Consistency
- Comparative analysis across production batches to ensure reproducibility and long-term assay stability.
Hybridization Robustness
- Performance validation across defined ranges of hybridization temperature and stringency.
Documentation and Traceability
- Complete QC records and test reports provided to support reproducibility and regulatory compliance.
Why Choose Us
One-stop solutions with in-house capabilities for probe design, synthesis, quantification, and analysis
Integrated service pipeline
Probe design, validation, and quality control workflows are optimized for high sensitivity and reproducibility in low-signal and complex hybridization applications.
High sensitivity and reproducibility
FFPE tissues, frozen tissue sections, cultured cells, blood samples, plant tissues, and single cells are all supported
Wide range of sample types
All products and services are supported by bioinformatics-driven design and assay optimization as well as expert data interpretation advice from experienced molecular biologists.
Expert science support
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