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Glomerulonephritis (GN) is an autoimmune disease that induces inflammation within the glomerulus and other compartments of the kidney. The clinical features encompass the formation of proteinuria and haematuria as well as low calculated glomerular filtration rate (GFR). Autoimmunity, cancer and structural abnormalities within kidney are involved in the pathogenesis of GN. However, the pathological mechanism of GN is still unclear. In addition, GN has been known as a common cause of chronic kidney disease (CKD) worldwide. It is associated with severe morbidity and thus represents a major socioeconomic health problem. Therefore, it is necessary for scientific research to look into an effective therapy for this significant clinical disease. Creative Bioarray specializes in providing customized pharmacodynamic research services to help customers assess the efficacy of drug candidates against glomerulonephritis and study the associated pathological mechanisms through glomerulonephritis models.
Figure. 1. Nephritis
Creative Bioarray provides you with Glomerulonephritis models including but not limited to:
Our Capabilities
Assays available
With extensive experience in the field of GN, we are confident to help you to overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Study examples
Figure. 2. Urinary protein excretion rate in the experimental groups.
Figure. 3. Representative renal morphology in the experimental groups at day 10 (a), and the glomerular damage score in groups A and B (b).
Quotation and ordering
If you have any special needs or questions regarding our services, please feel free to contact us at 631-626-9181 or info@creative-bioarray.com. We look forward to cooperating with you in the future.
Reference
Rampino T, Gregorini M , Bedino G , et al. Mesenchymal stromal cells improve renal injury in anti-Thy 1 nephritis by modulating inflammatory cytokines and scatter factors[J]. Clinical Science, 2011, 120(1):25-36.
For research use only. Not for any other purpose.
Disease Models:
Inflammation & Autoimmune Disease Models:
Glomerulonephritis Models:
Europe
Tel: 44-208-144-6005
Email: info@creative-bioarray.com