Oral Tumor Cells
Oral cancer, primarily comprising oral squamous cell carcinoma (OSCC), is a significant global health burden often associated with risk factors such as tobacco use, alcohol consumption, and increasingly, human papillomavirus (HPV) infection. These tumors are known for their high degree of local invasion and potential for early lymphatic metastasis.
Our oral tumor cell line collection offers a wide array of models derived from various anatomical sites, including the tongue, buccal mucosa, gingiva, and floor of the mouth. These cell lines are essential for studying oral carcinogenesis, investigating epithelial-mesenchymal transition (EMT), and testing novel targeted therapies or chemopreventive agents.
Anatomically Diverse Genetically Profiled Highly Invasive Validated
Key Features & Expertise
Our oral tumor cell lines are characterized to support precision research in head and neck squamous cell carcinoma (HNSCC):
Diverse Anatomical Origins
- Cell lines representing distinct oral cavity sites: Tongue (TSCC), Gingiva, and Palate.
- Availability of lines from different clinical stages, from early-stage dysplasias to advanced carcinomas.
- Models reflecting both HPV-positive and HPV-negative molecular backgrounds.
Molecular & Mechanistic Insights
- Characterized for common HNSCC mutations in TP53, CDKN2A, PIK3CA, and EGFR amplification.
- Ideal for studying key signaling pathways like TGF-β, Wnt/β-catenin, and Notch.
- Validated expression of biomarkers such as Cytokeratins, Vimentin, and E-cadherin.
Proven Experimental Performance
- STR-authenticated to ensure genetic consistency and eliminate cross-contamination.
- Highly suited for 2D/3D invasion assays and organotypic culture models.
- Consistent performance in cisplatin and cetuximab sensitivity/resistance studies.
FAQ
How do HPV-positive and HPV-negative oral tumor cell lines differ?
HPV-positive lines typically show wild-type TP53 and are often more sensitive to radiation, whereas HPV-negative lines (frequently associated with tobacco/alcohol) often harbor TP53 mutations and exhibit a more aggressive, treatment-resistant phenotype.
They are frequently used in migration and invasion assays due to their characterized aggressive behavior.
Can these cell lines be used to develop 3D organoid or skin-equivalent models?
Yes, many oral tumor cell lines can be co-cultured with fibroblasts in 3D collagen matrices to create organotypic models that better simulate the oral mucosal microenvironment and tumor-stroma interactions.
What is the importance of EGFR expression in oral cancer cells?
EGFR is frequently overexpressed in oral cancers and is a key therapeutic target. Our cell lines with confirmed EGFR status are excellent for testing EGFR inhibitors and investigating resistance mechanisms.
Are there normal oral epithelial cell lines available as controls?
We offer immortalized or primary human oral keratinocytes that serve as critical non-malignant controls for comparative studies on oncogenic transformation and drug cytotoxicity.
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Description: Established from the tumor of a 52-year-old Japanese man with highly differentiated squamous cell ...
Description: Established from the tumor of a 60-year-old Japanese man with moderately differentiated squamous ...
Description: The CAL-27 cells are established from the poorly differentiated squamous cell carcinoma of the ...
Description: Established from the surgically removed fragment of a tongue lesion from a 69-year-old man with ...
Description: Human cell line derived from squamous cell carcinoma at mouth floor.
Description: Human cell line derived from tongue cancer. Squamous cell carcinoma.
Description: Human tongue squamous cell carcinoma cell line. HLA-A 2/24.
Description: Human gingival carcinoma cell line. Expressing remarkable EGF receptor. HLA-A 2/24.
Description: Human tongue squamous cell carcinoma derived cell line.
Description: Human cell line derived from oral squamous cell carcinoma occurred in 69-yo, male patient. HLA-A ...
Description: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as ...
Description: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as ...
Description: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as ...
Description: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as ...
Description: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as ...
Description: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as ...
Description: G-CSF and IL-1 producing oral squamous cell carcinoma, the same patient as T3M-1 Clone2 and CJM.
Description: G-CSF producing oral squamous cell carcinoma, the same patient as T3M-1 Cl-10 and CJM. Cell growth ...