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Delayed-Type Hypersensitivity (DTH) Models

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Delayed-type hypersensitivity (DTH) is a useful model for assessing cell-mediated immune responses related to Th1 and Th17 reactivity. The delayed-type hypersensitivity reaction is mainly mediated by CD4+ or CD8+ T lymphocytes and consist of sensitization phase and challenge phase. The delayed-type hypersensitivity response is typically tested within 48 h after initial application.

Creative Bioarray, with a prestigious team in the industry, focuses on providing customized experiment services to help customers evaluate novel therapeutic interventions against DTH and study the basic mechanisms of DTH.

Delayed-type hypersensitivity (DTH) models include but not limited to:

  • keyhole limpet hemocyanin (KLH)-induced DTH model
  • oxazolone (OX)-induced DTH model

Our capabilities

  • We measure the differences in paw swelling and weight of mice after different treatments within 48 h post exposure.
  • We evaluate the impact of drug candidates on myeloperoxidase (MPO) activity and cytokine concentrations by Elisa assay.

Assays available

  • PK/PD blood collections
  • Histopathological evaluation
  • Cytokine analysis
  • Flow cytometry analysis

With extensive experience in the field of DTH, we are confident to help you to overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.

Study examples

Histopathological evaluation of cellular infiltrates in the ears from KLH induced mice treated with BIRB-796.Figure. 1. Histopathological evaluation of cellular infiltrates in the ears from KLH induced mice treated with BIRB-796.

oxazolone (OX)-induced DTH in K14-VEGF-A-tg mice differentially alters tissue cytokines, lymphatic drainage and DC migration at the DAY 2 and DAY 9 time point.Figure. 2. Oxazolone (OX)-induced DTH in K14-VEGF-A-tg mice differentially alters tissue cytokines, lymphatic drainage and DC migration at the DAY 2 and DAY 9 time point.

Quotation and ordering

If you have any special needs or questions regarding our services, please feel free to contact us at 631-626-9181 or . We look forward to cooperating with you in the future.

References

  1. Aebischer D, Willrodt A H, Halin C. Oxazolone-Induced Contact Hypersensitivity Reduces Lymphatic Drainage but Enhances the Induction of Adaptive Immunity[J]. PLOS ONE, 2014, 9.
  2. Engstrom L, et al. Characterization of a murine keyhole limpet hemocyanin (KLH)-delayed-type hypersensitivity (DTH) model: Role for p38 kinase[J]. International Immunopharmacology, 2009, 9(10):0-1227.

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