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Delayed-type hypersensitivity (DTH) is a useful model for assessing cell-mediated immune responses related to Th1 and Th17 reactivity. The delayed-type hypersensitivity reaction is mainly mediated by CD4+ or CD8+ T lymphocytes and consist of sensitization phase and challenge phase. The delayed-type hypersensitivity response is typically tested within 48 h after initial application.
Creative Bioarray, with a prestigious team in the industry, focuses on providing customized experiment services to help customers evaluate novel therapeutic interventions against DTH and study the basic mechanisms of DTH.
Delayed-type hypersensitivity (DTH) models include but not limited to:
With extensive experience in the field of DTH, we are confident to help you to overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Figure. 1. Histopathological evaluation of cellular infiltrates in the ears from KLH induced mice treated with BIRB-796.
Figure. 2. Oxazolone (OX)-induced DTH in K14-VEGF-A-tg mice differentially alters tissue cytokines, lymphatic drainage and DC migration at the DAY 2 and DAY 9 time point.
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Inflammation & Autoimmune Disease Models: