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Cardiovascular Disease Models

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Cardiovascular diseases are the leading cause of death and morbidity in many countries, which affect the heart and blood vessels, leading to a variety of consequences including ischemia, stroke, angina pectoris, and cardiomyopathy. Although investment in cardiovascular drug development is increasing, the number of drugs approved by the FDA is declining. This is due to the cardiotoxicity of many drugs that target cardiovascular diseases and the highest incidence and severity of adverse drug reactions in late clinical development.

Cardiovascular Disease Models

At Creative Bioarray, we have successfully developed various cardiovascular models to help developing drugs for cardiovascular diseases. The application of animal models helps increase our understanding of cardiovascular diseases and provides new approaches to improve the diagnosis and treatment of the diseases. In addition, these models can also be used for screening of adverse drug reactions. Besides, in vitro and in silicon models have recently been proposed to assist in assessing cardiotoxicity.

We provide a variety of models and key technologies of CVD to help with the development of your new compounds. We can also help design the best scheme accordingly using the following models.

Our portfolio of cardiovascular disease models covers the following diseases

  • Atherosclerosis
  • Carotid artery ligation
  • Hypertension
  • Restenosis following carotid balloon angioplasty
  • Chemically-induced carotid thrombus formation
  • Thrombosis
  • Middle cerebral artery occlusion (MCAO)
  • Spontaneously hypertensive (SHR)
  • Cardiac ischemia / reperfusion
  • Hyperlipidemia

We typically combine various endpoints to obtain the high quality and repeatable data needed for the project. All experimental models were tested in a dose-dependent manner using an approved positive control. We also have the flexibility and expertise to develop custom in vivo models to meet your specific needs.

Our capabilities for analyses include but not limited to

  • Cardiac dysfunction
  • Cardiac hypertrophy
  • Endothelial dysfunction
  • Blood pressure monitoring
  • Vascular stiffening

Data & Figures

Cardiovascular Disease Models Figure 1. Histology of infarcted hearts. Four weeks after infarction, hearts were excised, sectioned at the level of the papillary muscles, and stained with Masson’s trichrome.

Quotation and ordering

We have extensive experience in developing disease models based on scientific publications. To discuss any of these models further or to discuss the possibility of developing alternative models, please do not hesitate to contact us at or 1-631-626-9181.

Reference

  1. Kido, M. et al. Hypoxia-Inducible Factor 1-Alpha Reduces Infarction and Attenuates Progression of Cardiac Dysfunction After Myocardial Infarction in the Mouse. J. Am. Coll. Cardiol. 46, 2116–2124 (2005).

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CONTACT US USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
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Tel: 44-207-097-1828
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