Skin Aging and Anti-aging

Skin Aging and Anti-aging

Skin is the largest and the most visible organ of the human body. Aged skin is biologically characterized by the flattening of the dermal-epidermal junction and a general atrophy of the extracellular matrix (ECM) with disorganized and reduced collagen and elastin. Skin aging reflects the naturally occurring changes in the skin as we age, and can also be accelerated due to exposure of the skin to sunlight and/or air pollution and is phenotypically demonstrated as dry, rough, pigmented and abraded skin especially in the face and hands.

In the past few years, significant progress has been made in the understanding of cell ageing mechanisms and we can now explore new dermo-cosmetics strategies which might prevent or decelerate the signs of ageing. The demand for an anti-aging therapy is higher day by day. A lot of treatments are available for skin aging now: pharmaceutical, surgical and cosmetic solutions, which aim to change the nature of aging collagen, stretching the skin, filling in the depressions of the skin and etc.

In order to identify most efficient applications of the new ingredients of anti-aging, the need for in vitro testing in cosmetic or dermatological industries is greatly growing nowadays, because of below aspects: firstly, regulatory affairs that include consumer safety and strict ban of animal use in testing. Secondly, there is a big advantage regarding research and development because of faster screening and access to more informative tests. Finally, this leads to on the evidence based communication with consumers.

Your Needs

  • You wish to screen ingredients, and characterize the efficacy or toxicity or safety of any products or chemicals of anti-aging?
  • You’d like to find a customized service of skin aging or anti-aging?

Our Capability

Creative Bioarray provides in vitro 3D skin tissue models and evaluation assays performed for cosmetic or dermatological efficacy and claims support of anti-aging.

In vitro 3D skin models available

Assays available

  • Evaluating efficacy, safety or toxicity of compounds for anti-aging
  • Evaluating effects of different formulations, ingredients
  • Other customized assays


  • Deposition of collagen, elastin, hyaluronic acid (mRNA, protein)
  • MMPs production (mRNA, protein, proteolytic activity)
  • Glycosaminoglycans (GAGs)
  • Reactive oxygen species (H2DCFDA)
  • Dermal markers: Fibrillin, Vimentin, collagen I, collagen III and elastin
  • Dermal-epidermal junction markers: Integrin B4, Laminin 5
  • Proliferation, migration, differentiation and apoptosis
  • DNA damage
  • Free radical production


  • qPCR, qPCRarray, RT-PCR
  • Epidermal separation
  • Immunofluorescence
  • RNA extraction
  • Protein extraction
  • Macroscopy

Assay Examples

Percent increase of collagen synthesis versus untreated control by treatment and by dose Fig 1. Percent increase of collagen synthesis versus untreated control by treatment and by dose

Related Products and Services

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In vitro Skin Models:

For research use only. Not for any other purpose.