Alzheimer's Disease Study Tools

Alzheimer's disease (AD) is the most common form of dementia and characterized by learning and memory impairment involving extremely complex mechanisms. Creative Bioarray provides a full range of assays which have been extensively practiced in the development of preclinical drugs targeting Alzheimer's disease. Our assays include all kinds of behavioral tests that evaluate changes in general cognitive function of the animals, neurological Imaging that reveals the three-dimensional anatomical structure and function of animal brain, electrophysiology assays that demonstrate neuronal properties (patch-clamp) in brain slices or overall activity (EEG) in animal brain. In addition, we, as always, embrace any newer, updated and advanced techniques developed by the field, and our effort will always be made to incorporate every possible approach to facilitate your research.

Figure. 1. Neuropathy of dementia

Alzheimer's Disease Study Tools include but not limited to:

• Behavior Tests
• Cognitive Functions Tests
• Sensory Function Tests
• Motor Function Tests
• Social Interaction
• Gait and Balance Changes
• Neurological Imaging
• MRI, PET/CT, and SPECT/CT
• Electrophysiology Assay
• Long-term Potentiation (LTP) Assay
• Patch Clamp
• EEG Monitoring
• Microdialysis

Our extensive experience enables us for any comprehensive tests in Alzheimer's disease research. With professions in customized protocols and assays to precisely meet client’s need, our experts are fully capable and easy to communicate.

Study examples

Figure. 2. Longitudinal and cross-sectional voxel-wise differences between TgCRND8 (TG) and WT mice. A. Significant voxel-wise volume differences between TG and WT longitudinally scanned at 9, 12, 16 and 20 weeks of age. Areas of the brain highlighted in blue represent regions where TG mice were significantly smaller than WT at a particular age; red represent regions where TG are significantly larger than WT (t-statistic= ±2.46, 5% FDR). Top left: Sagittal image of the final non-linear average depicting the location of the coronal slice selection through the brain. Rows: Corresponding coronal slices in the rostral to caudal direction (iv). Columns: The first column: Labels of brain regions overlaid on the anatomy (AMY, amygdala; ACC, anterior cingulated cortex; BNST, bed nucleus of the stria terminalis; CBL, cerebellum; dHIP, dorsal hippocampus, vHIP, ventral hippocampus; HYP, hypothalamus; MED, medulla; MID, midbrain; MO, motor cortex; RSC, retrosplenial cortex; SS, somatosensory cortex; THM, thalamus; VIS, visual cortex). Columns 2-5: 9, 12, 16 and 20 weeks of age. B. Results from the cross-sectional volumetric analysis between TG and WT mice at 9, 12, 16, or 20 weeks of age (Blue: TG < WT; Red: TG > WT; t-statistic= ±2.92, 5% FDR)

Quotation and ordering

If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.

Reference

1. Allemang-Grand R et al. Altered brain development in an early-onset murine model of Alzheimer's disease. Neurobiology of Aging. 2015; 36: 638-47.

For research use only. Not for any other purpose.