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The oral mucosa is the term used to describe the soft tissue lining of the oral cavity, including the buccal mucosa and the gingivae. Human oral mucosa presents several chemical and physical barriers to transmucosal absorption to avoid toxicity.
Tissue-engineered 3D culture systems of the oral mucosa were developed and have been used to study the responses of the human oral mucosa to external stimuli in vitro, which has been an alternative to expensive clinical or whole animal testing.
With over 10 years’ experience of working on cell & tissue products and services, Creative Bioarray provides in vitro oral & gingival mucosa model and in vitro oral & gingival irritation, toxicology testing services to help oral care, personal care, and pharmaceutical companies evaluate their raw materials and final product formulations.
- Creative Bioarray's in vitro Oral Mucosa model could be applied to in vitro oral irritation, toxicity, tolerance test, and in vitro dental material assessment. The models are very similar to in vivo mucosa in terms of morphology, of differentiation markers and of functional characteristics.
Fig.1. Histologic characterization of the 3D model of oral mucosa. (a) Morphologic characteristics (H&E staining). (b) Expression pattern of E-cadherin (immunohistochemical staining). (c) Expression pattern of Ki-67 (immunohistochemical staining).
Fig.2. Cell viability test result for different oral care products.
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