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Disease Models - Related Articles

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202220232024
2022

Elevated CD47 Is a Hallmark of Aged Muscle Stem Cells

Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, Hilgendorf KI, Frésard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM. (2022). Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration. Cell Stem Cell. 29 (12), 1653-1668.

Analysis of Molecular Classification and Biomarkers in Breast Ductal Carcinoma in Situ

Strand SH, et al. (2022). Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts. Cancer Cell. S1535-6108 (22), 00512-8.

Myeloid Cells Promote Deterioration of the Hematopoietic System

Feyen J, Ping Z, Chen L, van Dijk C, van Tienhoven TVD, van Strien PMH, Hoogenboezem RM, Wevers MJW, Sanders MA, Touw IP, Raaijmakers MHGP. (2022). Myeloid cells promote interferon signaling-associated deterioration of the hematopoietic system. Nature Communications. 13 (1), 7657.

SYK Coordinates Neuroprotective Microglial Responses

Ennerfelt H, Frost EL, Shapiro DA, Holliday C, Zengeler KE, Voithofer G, Bolte AC, Lammert CR, Kulas JA, Ulland TK, Lukens JR. (2022). SYK coordinates neuroprotective microglial responses in neurodegenerative disease. Cell. 185 (22), 4135-4152.

A Reference Human Induced Pluripotent Stem Cell Line

Pantazis CB, et al. (2022). A reference human induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell. 29(12), 1685-1702.
2023

Report on Generation of iPSC Lines from PBMCs

Gao Y, Cheng Y, Wen J, Xiao D, Xu J, Cai C, Hu J. (2023). Efficient generation of induced pluripotent stem cell lines from peripheral blood mononuclear cells. Stem Cell Research. 69: 103088.

Overview of Liver Organoid Models

Iqbal W, Wang Y, Sun P, Zhou X. (2023). Modeling Liver Development and Disease in a Dish. International Journal of Molecular Sciences. 24 (21): 15921.

Pluripotent Stem Cell-Based 3D Embryo Model

Ávila-González D, Gidi-Grenat MÁ, García-López G, Martínez-Juárez A, Molina-Hernández A, Portillo W, Díaz-Martínez NE, Díaz NF. (2023). Pluripotent Stem Cells as a Model for Human Embryogenesis. Cells. 12 (8), 1192.

CAR-Cell Therapy for Solid Tumors

Maalej KM, Merhi M, Inchakalody VP, Mestiri S, Alam M, Maccalli C, Cherif H, Uddin S, Steinhoff M, Marincola FM, Dermime S. (2023). CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances. Molecular Cancer. 22 (1), 20.

Biological Behaviors of Targeted Breast Cancer Stem Cells

Zhang L, Chen W, Liu S, Chen C. (2023). Targeting Breast Cancer Stem Cells. International Journal of Biological Sciences. 19 (2), 552-570.

Diverse Biological Functions of Extracellular Vesicles

Karnas E, Dudek P, Zuba-Surma EK. (2023). Stem cell-derived extracellular vesicles as new tools in regenerative medicine - Immunomodulatory role and future perspectives. Frontiers in Immunology. 14, 11201759.

In Vitro Cellular Reprogramming to Model Disorders of Sex Development

Gonen N, Eozenou C, Mitter R, Elzaiat M, Stévant I, Aviram R, Bernardo AS, Chervova A, Wankanit S, Frachon E, Commère PH, Brailly-Tabard S, Valon L, Barrio Cano L, Levayer R, Mazen I, Gobaa S, Smith JC, McElreavey K, Lovell-Badge R, Bashamboo A. (2023). In vitro cellular reprogramming to model gonad development and its disorders. Science Advances. 9(1), eabn9793.

Senescent Cells Perturb Intestinal Stem Cell Differentiation Through Ptk7

Yun J, Hansen S, Morris O, Madden DT, Libeu CP, Kumar AJ, Wehrfritz C, Nile AH, Zhang Y, Zhou L, Liang Y, Modrusan Z, Chen MB, Overall CC, Garfield D, Campisi J, Schilling B, Hannoush RN, Jasper H. (2023). Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling. Nature Communications. 14(1), 156.

Neural Progenitor Cell Village Reveals Natural Variation

Wells MF, Nemesh J, Ghosh S, Mitchell JM, Salick MR, Mello CJ, Meyer D, Pietilainen O, Piccioni F, Guss EJ, Raghunathan K, Tegtmeyer M, Hawes D, Neumann A, Worringer KA, Ho D, Kommineni S, Chan K, Peterson BK, Raymond JJ, Gold JT, Siekmann MT, Zuccaro E, Nehme R, Kaykas A, Eggan K, McCarroll SA. (2023). Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages. Cell Stem Cell. S1934-5909(23)00035-8.

Inactive Disease in Lupus Patients Normalizes Ifnα and B-Cell Subsets

Bradford HF, Haljasmägi L, Menon M, McDonnell TCR, Särekannu K, Vanker M, Peterson P, Wincup C, Abida R, Gonzalez RF, Bondet V, Duffy D, Isenberg DA, Kisand K, Mauri C. (2023). Inactive disease in patients with lupus is linked to autoantibodies to type I interferons that normalize blood IFNα and B cell subsets. Cell Reports Medicine. 4 (1), 100894.

Design of Human Stem Cell-Derived Islets

Gerace D, Zhou Q, Kenty JH, Veres A, Sintov E, Wang X, Boulanger KR, Li H, Melton DA. (2023). Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance. Cell Reports Medicine. 4 (1), 100879.

Multiscale 3D Genome Reorganization of Skeletal Muscle Stem Cells

Zhao Y, Ding Y, He L, Zhou Q, Chen X, Li Y, Alfonsi MV, Wu Z, Sun H, Wang H. (2023). Multiscale 3D genome reorganization during skeletal muscle stem cell lineage progression and aging. Science Advances. 9 (7): eabo1360.

Generation of iPSC Lines from LQTS Patients

Jimenez-Tellez N, Vera CD, Yildirim Z, Vicente Guevara J, Zhang T, Wu JC. (2023). Generation of two iPSC lines from long QT syndrome patients carrying SNTA1 variants. Stem Cell Research. 66: 103003.

Generation of NRF2 Knockout iPSC Clones Using CRISPR/Cas9 Editing

Merkert S, Haase A, Dahlmann J, Göhring G, Waqas FH, Pessler F, Martin U, Olmer R. (2023). Generation of two human NRF2 knockout iPSC clones using CRISPR/Cas9 editing. Stem Cell Research. 69: 103090.

Characterization of Transplantation of Human iPSC Neuronal Precursors

Kobayashi Y, Shigyo M, Platoshyn O, Marsala S, Kato T Jr, Takamura N, Yoshida K, Kishino A, Bravo-Hernandez M, Juhas S, Juhasova J, Studenovska H, Proks V, Driscoll SP, Glenn TD, Pfaff SL, Ciacci JD, Marsala M. (2023). Expandable Sendai-Virus-Reprogrammed Human iPSC-Neuronal Precursors: In Vivo Post-Grafting Safety Characterization in Rats and Adult Pig. Cell Transplantation. 32: 9636897221107009.

Characterization of Human-Induced Pluripotent Stem Cells

Suresh Babu S, Duvvuru H, Baker J, Switalski S, Shafa M, Panchalingam KM, Dadgar S, Beller J, Ahmadian Baghbaderani B. (2023). Characterization of human induced pluripotent stem cells: Current approaches, challenges, and future solutions. Biotechnology Reports. 37: e00784.

Roles of HHEX in Pancreatic Endoderm Differentiation

Ito R, Kimura A, Hirose Y, Hatano Y, Mima A, Mae SI, Keidai Y, Nakamura T, Fujikura J, Nishi Y, Ohta A, Toyoda T, Inagaki N, Osafune K. (2023). Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model. Scientific Reports. 13 (1): 8659.
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2024

Impacts of NK Cell-Surface Receptors on CAR-NK Efficacy in Solid Tumors

Wang W, Liu Y, He Z, Li L, Liu S, Jiang M, Zhao B, Deng M, Wang W, Mi X, Sun Z, Ge X. (2024). Breakthrough of solid tumor treatment: CAR-NK immunotherapy. Cell Death Discovery. 10 (1): 40.

Histology – Related Articles

20222023
2022

Comparative Research of IHC and FISH in HER 2 / Neu Gene Detection

Aznab M, Izadi B, Amirian F, Khazaei S, Madani SH, Ramezani M. (2022). Comparison of Immunohistochemical Methods (IHC) and Fluorescent in Situ Hybridization (FISH) in the Detection of HER 2 /Neu Gene in Kurdish Patients with Breast Cancer in Western Iran. International Journal of Hematology-Oncology Stem Cell Research. 16 (4), 217-223.

Analysis of Molecular Classification and Biomarkers in Breast Ductal Carcinoma in Situ

Strand SH, et al. (2022). Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts. Cancer Cell. S1535-6108 (22), 00512-8.
2023

A Novel Method for Detection of IGH::CRLF2 Gene Fusions by FISH

González-Arreola RM, García-Romero A, Magaña-Torres MT, González-García JR. (2023). A novel approach for direct detection of the IGH::CRLF2 gene fusion by fluorescent in situ hybridization. Molecular Cytogenetics. 16 (1): 19.

Identification of Lymphatic Glycocalyx by TEM and IHC

Gianesini S, Rimondi E, Raffetto JD, Melloni E, Pellati A, Menegatti E, Avruscio GP, Bassetto F, Costa AL, Rockson S. (2023). Human collecting lymphatic glycocalyx identification by electron microscopy and immunohistochemistry. Scientific Reports. 13 (1), 3022.

Study of Polyploidy Leading to False Positives in FISH

van Gulik AL, Sluydts E, Vervoort L, Kockx M, Kortman P, Ylstra B, Finn SP, Bubendorf L, Bahce I, Sie D, Radonic T, Lissenberg-Witte B, Thunnissen E. (2023). False positivity in break apart fluorescence in-situ hybridization due to polyploidy. Translation Lung Cancer Research. 12 (4), 676-688.

Microscopy Studies of Synapses in Alzheimer's Disease Tissue

Griffiths J and Grant SGN. (2023). Synapse pathology in Alzheimer's disease. Seminars in Cell & Development Biology. 139, 13-23.

Senescent Cells Perturb Intestinal Stem Cell Differentiation Through Ptk7

Yun J, Hansen S, Morris O, Madden DT, Libeu CP, Kumar AJ, Wehrfritz C, Nile AH, Zhang Y, Zhou L, Liang Y, Modrusan Z, Chen MB, Overall CC, Garfield D, Campisi J, Schilling B, Hannoush RN, Jasper H. (2023). Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling. Nature Communications. 14(1), 156.

Dual-Modality Imaging of IF and IMC

Kim EN, Chen PZ, Bressan D, Tripathi M, Miremadi A, di  Pietro M, Coussens LM, Hannon GJ, Fitzgerald RC, Zhuang L, Chang YH. (2023). Dual-modality  imaging of immunofluorescence and imaging mass cytometry for whole slide  imaging with accurate single-cell segmentation. BioRxiv [Preprint]. 2023.02.23:  529718.

Deep Immunohistochemistry for 3D Histology

Yau CN, Lai HM, Lee K, Kwok AJ, Huang J, Ko H.  (2023). Principles of deep immunohistochemistry for 3D histology. Cell Reports  Methods. 3 (5): 100458.

Visualization of Inflammatory Gene Products in Neuronal Cells by RNAscope and IHC

Ball JB, McNulty CJ, Green-Fulgham SM, Dragavon JM, Correia Rocha IR, Finch MR, Prévost ED, Siddique II, Woodall BJ, Watkins LR, Baratta MV, Root DH. (2023). Combining RNAscope and immunohistochemistry to visualize inflammatory gene products in neurons and microglia. Frontier in Molecular Neuroscience. 16: 1225847.

Biofilm Imaging with FISH

Barbosa A, Miranda S, Azevedo NF, Cerqueira L, Azevedo AS. (2023). Imaging biofilms using fluorescence in situ hybridization: seeing is believing. Frontiers in Cellular Infection Microbiology. 13: 1195803

Exosome - Related Articles

202220232024
2022

Exosome-Mediated Delivery of Cas9 Ribonucleoprotein Complexes

Wan T, Zhong J, Pan Q, Zhou T, Ping Y, Liu X. (2022). Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases. Science Advance. 8 (37), eabp9435.

An Exosome-Related RNA Risk Model for Predicting Breast Cancer

Qiu P, Guo Q, Lin J, Pan K, Chen J, Ding M. (2022). An exosome-related long non-coding RNAs risk model could predict survival outcomes in patients with breast cancer. Scientific Reports. 12(1), 22322.

Application of Exosomes in Clinical Trials

Rezaie J, Feghhi M, Etemadi T. (2022). A review on exosomes application in clinical trials: perspective, questions, and challenges. Cell Communication and Signaling. 20 (1), 145.
2023

Exosomes in Virus Infection

Peng Y, Yang Y, Li Y, Shi T, Luan Y, Yin C. (2023). Exosome and virus infection. Frontiers in Immunology. 14: 1154217.

Report of Protein Overproduction Inducing Exosome Secretion

Steć A, Targońska M, Karkosińska E, Słowik M, Płoska A, Kalinowski L, Wielgomas B, Waleron K, Jasiecki J, Dziomba S. (2023). Protein overproduction alters exosome secretion in Chinese hamster ovary cells. Analytical and Bioanalytical Chemistry. 415 (16): 3167-3176.

Exosome Secretion and Uptake Involved in Cancer Therapy

Lau NCH and Yam JWP. (2023). From Exosome Biogenesis to Absorption: Key Takeaways for Cancer Research. Cancers (Basel). 15 (7), 1992.

An Exosome-Related RNA Risk Model for Predicting Breast Cancer

Qiu P, Guo Q, Lin J, Pan K, Chen J, Ding M. (2022). An exosome-related long non-coding RNAs risk model could predict survival outcomes in patients with breast cancer. Scientific Reports. 12(1), 22322.

Drug Loading Approaches of Exosomes

Kar R, Dhar R, Mukherjee S, Nag S, Gorai S, Mukerjee N, Mukherjee D, Vatsa R, Chandrakanth Jadhav M, Ghosh A, Devi A, Krishnan A, Thorat ND. (2023). Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics. ACS Biomaterials Science Engineering. 9 (2): 577-594.

Isolation and Characterization of Exosomes from Non-Small Lung Cancer Cells

Mahgoub EO, Abdella GM. (2023). Improved exosome isolation methods from non-small lung cancer cells (NC1975) and their characterization using morphological and surface protein biomarker methods. Journal of Cancer Research and Clinical Oncology. 149 (10): 7505-7514.

Applications Exosomes in Inflammatory Diseases

Yang Y, Peng Y, Li Y, Shi T, Luan Y, Yin C. (2023).  Role of stem cell derivatives in inflammatory diseases. Frontiers in Immunology.  14: 1153901.

2024

Exosomes as Biomarkers for Neurodegenerative Disorders

Huber CC, Wang H. (2024). Pathogenic and therapeutic role of exosomes in neurodegenerative disorders. Neural Regeneration Research. 19 (1): 75-79.

Cancer - Related Articles

202220232024
2022

Comparative Research of IHC and FISH in HER 2 / Neu Gene Detection

Aznab M, Izadi B, Amirian F, Khazaei S, Madani SH, Ramezani M. (2022). Comparison of Immunohistochemical Methods (IHC) and Fluorescent in Situ Hybridization (FISH) in the Detection of HER 2 /Neu Gene in Kurdish Patients with Breast Cancer in Western Iran. International Journal of Hematology-Oncology Stem Cell Research. 16 (4), 217-223.

Chemoresistance to Cisplatin in Cancer Therapy

Ranasinghe R, Mathai ML, Zulli A. (2022). Cisplatin for cancer therapy and overcoming chemoresistance. Heliyon. 8 (9): e10608.
2023

Study of Polyploidy Leading to False Positives in FISH

van Gulik AL, Sluydts E, Vervoort L, Kockx M, Kortman P, Ylstra B, Finn SP, Bubendorf L, Bahce I, Sie D, Radonic T, Lissenberg-Witte B, Thunnissen E. (2023). False positivity in break apart fluorescence in-situ hybridization due to polyploidy. Translation Lung Cancer Research. 12 (4), 676-688.

Exosome Secretion and Uptake Involved in Cancer Therapy

Lau NCH and Yam JWP. (2023). From Exosome Biogenesis to Absorption: Key Takeaways for Cancer Research. Cancers (Basel). 15 (7), 1992.

Reprogramming of Neutrophils by Lung Mesenchymal Cells

Gong Z, Li Q, Shi J, Li P, Hua L, Shultz LD, Ren G. (2023). Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis. Science Immunology. 8 (80): eadd5204.

Roles of MSC-EVs in Cancer Therapy

Nicodemou A, Bernátová S, Čeháková M, Danišovič Ľ. (2023). Emerging Roles of Mesenchymal Stem/Stromal-Cell-Derived Extracellular Vesicles in Cancer Therapy. Pharmaceutics. 15 (5), 1453.

Establishment of a New Pancreatic Cancer Cell Line

Xu H, Chai CP, Miao X, Tang H, Hu JJ, Zhang H, Zhou WC. (2023). Establishment and characterization of a new human ampullary carcinoma cell line, DPC-X1. World Journal of Gastroenterology. 29 (17), 2642-2656.

Immortalized Murine Tenocyte Cells for Tendon Research

Oreff GL, Maurer B, ELKhamary AN, Gerner I, Sexl V, Jenner F. (2023). Immortalized murine tenocyte cells: a novel and innovative tool for tendon research. Scientific Reports. 13 (1), 1566.

Studies on Prostate Tumor Cells Triggered by Photodynamic Therapy

de Melo Gomes LC, de Oliveira Cunha AB, Peixoto LFF, Zanon RG, Botelho FV, Silva MJB, Pinto-Fochi ME, Góes RM, de Paoli F, Ribeiro DL. (2023). Photodynamic therapy reduces cell viability, migration and triggers necroptosis in prostate tumor cells. Photochemical & Photobiological Sciences. 22 (6), 1341-1356.

Isolation and Characterization of Exosomes from Non-Small Lung Cancer Cells

Mahgoub EO, Abdella GM. (2023). Improved exosome isolation methods from non-small lung cancer cells (NC1975) and their characterization using morphological and surface protein biomarker methods. Journal of Cancer Research and Clinical Oncology. 149 (10): 7505-7514.

Cancer Organoid Co-culture Model Systems

Yuan J, Li X, Yu S. (2023). Cancer organoid co-culture model system: Novel approach to guide precision medicine. Frontiers in Immunology. 13: 1061388.

Biological Features of Circulating Tumor Cells

Ring A, Nguyen-Sträuli BD, Wicki A, Aceto N. (2023). Biology, vulnerabilities and clinical applications of circulating tumor cells. Nature Reviews Cancer. 23 (2): 95-111.

Ovarian Cancer Stem Cell-Related Signaling Pathways

Ma H, Tian T, Cui Z. (2023). Targeting ovarian cancer stem cells: a new way out. Stem Cell Research and Therapy. 14 (1): 28.

2024

Impacts of NK Cell-Surface Receptors on CAR-NK Efficacy in Solid Tumors

Wang W, Liu Y, He Z, Li L, Liu S, Jiang M, Zhao B, Deng M, Wang W, Mi X, Sun Z, Ge X. (2024). Breakthrough of solid tumor treatment: CAR-NK immunotherapy. Cell Death Discovery. 10 (1): 40.

Cell Medicine Articles

20222023
2022

Application of aCGH for Identification of Chromosomal Aberrations

Kowalczyk K, Smyk M, Bartnik-Głaska M, Plaskota I, Wiśniowiecka-Kowalnik B, Bernaciak J, Chojnacka M, Paczkowska M, Niemiec M, Dutkiewicz D, Kozar A, Magdziak R, Krawczyk W, Pietras G, Michalak E, Klepacka T, Obersztyn E, Bal J, Nowakowska BA. (2022). Application of array comparative genomic hybridization (aCGH) for identification of chromosomal aberrations in the recurrent pregnancy loss. Journal of Assisted Reproduction and Genetics. 39 (2), 357-367.
2023

Measurement of Telomere Length Dynamics by Flow-FISH

Rolles B, Ferreira MSV, Vieri M, Rheinwalt KP, Schmitz SM, Alizai PH, Neumann U, Brümmendorf TH, Beier F, Ulmer TF, Tometten M. (2023). Telomere length dynamics measured by flow-FISH in patients with obesity undergoing bariatric surgery. Scientific Reports. 13 (1), 304.

CAR-Cell Therapy for Solid Tumors

Maalej KM, Merhi M, Inchakalody VP, Mestiri S, Alam M, Maccalli C, Cherif H, Uddin S, Steinhoff M, Marincola FM, Dermime S. (2023). CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances. Molecular Cancer. 22 (1), 20.

Inactive Disease in Lupus Patients Normalizes Ifnα and B-Cell Subsets

Bradford HF, Haljasmägi L, Menon M, McDonnell TCR, Särekannu K, Vanker M, Peterson P, Wincup C, Abida R, Gonzalez RF, Bondet V, Duffy D, Isenberg DA, Kisand K, Mauri C. (2023). Inactive disease in patients with lupus is linked to autoantibodies to type I interferons that normalize blood IFNα and B cell subsets. Cell Reports Medicine. 4 (1), 100894.

Design of Human Stem Cell-Derived Islets

Gerace D, Zhou Q, Kenty JH, Veres A, Sintov E, Wang X, Boulanger KR, Li H, Melton DA. (2023). Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance. Cell Reports Medicine. 4 (1), 100879.

Different Animal Model Systems for Parkinson’s Disease

Khan E, Hasan I, Haque ME. (2023). Parkinson's Disease: Exploring Different Animal Model Systems. International Journal of Molecular Sciences. 24 (10), 9088.

A Novel Rodent Model of Sporadic Alzheimer’s Disease

Chadwick W, Maudsley S, Hull W, Havolli E, Boshoff E, Hill MDW, Goetghebeur PJD, Harrison DC, Nizami S, Bedford DC, Coope G, Real K, Thiemermann C, Maycox P, Carlton M, Cole SL. (2023). The oDGal Mouse: A Novel, Physiologically Relevant Rodent Model of Sporadic Alzheimer's Disease. International Journal of Molecular Science.24 (8), 6953.

Investigation of Simplified Physiologically-Based Pharmacokinetic Models

Yau E, Olivares-Morales A, Ogungbenro K, Aarons L, Gertz M. (2023). Investigation of simplified physiologically-based pharmacokinetic models in rat and human. CPT Pharmacometrics and Systems Pharmacology. 12 (3), 333-345.

Toxicokinetic Characterization of Hexamethylenetetramine

Kim W, Kim E, Lee J, Song CH, Jung W, Shin S, Kim KB, Shin BS, Kim TH. (2023). Development of an LC-MS/MS Assay and Toxicokinetic Characterization of Hexamethylenetetramine in Rats. Toxics. 11 (4), 337.

A Study of the Effect of Drug Combinations on Angiogenesis

Qadir A, Samad DA, Asif M, Ali MM, Zain S. (2023). Investigating the effect of vandetanib and celecoxib combination on angiogenesis. Journal of Taibah University Medical Sciences. 18 (5), 1011-1017.

Generation of iPSC Lines from LQTS Patients

Jimenez-Tellez N, Vera CD, Yildirim Z, Vicente Guevara J, Zhang T, Wu JC. (2023). Generation of two iPSC lines from long QT syndrome patients carrying SNTA1 variants. Stem Cell Research. 66: 103003.

Generation of NRF2 Knockout iPSC Clones Using CRISPR/Cas9 Editing

Merkert S, Haase A, Dahlmann J, Göhring G, Waqas FH, Pessler F, Martin U, Olmer R. (2023). Generation of two human NRF2 knockout iPSC clones using CRISPR/Cas9 editing. Stem Cell Research. 69: 103090.

Assessment of MDPV Permeability Across the Caco-2 Monolayer

Almeida AS, Silva B, Remião F, Fernandes C. (2023). Assessment of the Permeability of 3,4-Methylenedioxypyrovalerone (MDPV) across the Caco-2 Monolayer for Estimation of Intestinal Absorption and Enantioselectivity. International Journal of Molecular Sciences. 24 (3): 2680.

A Novel in Vitro Model of Intestinal Epithelial Drug Permeability

Cheng Y, Watanabe C, Ando Y, Kitaoka S, Egawa Y, Takashima T, Matsumoto A, Murakami M. (2023). Caco-2 Cell Sheet Partially Laminated with HT29-MTX Cells as a Novel In Vitro Model of Gut Epithelium Drug Permeability. Pharmaceutics. 15 (9): 2338.

Disease Models - Related Articles

20222023
2022

SYK Coordinates Neuroprotective Microglial Responses

Ennerfelt H, Frost EL, Shapiro DA, Holliday C, Zengeler KE, Voithofer G, Bolte AC, Lammert CR, Kulas JA, Ulland TK, Lukens JR. (2022). SYK coordinates neuroprotective microglial responses in neurodegenerative disease. Cell. 185 (22), 4135-4152.

An Exosome-Related RNA Risk Model for Predicting Breast Cancer

Qiu P, Guo Q, Lin J, Pan K, Chen J, Ding M. (2022). An exosome-related long non-coding RNAs risk model could predict survival outcomes in patients with breast cancer. Scientific Reports. 12(1), 22322.

Inhibition of Lin28 Restores Lipid Homeostasis in Disease Models

Lekka E, Kokanovic A, Mosole S, Civenni G, Schmidli S, Laski A, Ghidini A, Iyer P, Berk C, Behera A, Catapano CV, Hall J. (2022). Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease. Nature Communications. 13(1), 7940.
2023

CAR-Cell Therapy for Solid Tumors

Maalej KM, Merhi M, Inchakalody VP, Mestiri S, Alam M, Maccalli C, Cherif H, Uddin S, Steinhoff M, Marincola FM, Dermime S. (2023). CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances. Molecular Cancer. 22 (1), 20.

Biological Behaviors of Targeted Breast Cancer Stem Cells

Zhang L, Chen W, Liu S, Chen C. (2023). Targeting Breast Cancer Stem Cells. International Journal of Biological Sciences. 19 (2), 552-570.

In Vitro Cellular Reprogramming to Model Disorders of Sex Development

Gonen N, Eozenou C, Mitter R, Elzaiat M, Stévant I, Aviram R, Bernardo AS, Chervova A, Wankanit S, Frachon E, Commère PH, Brailly-Tabard S, Valon L, Barrio Cano L, Levayer R, Mazen I, Gobaa S, Smith JC, McElreavey K, Lovell-Badge R, Bashamboo A. (2023). In vitro cellular reprogramming to model gonad development and its disorders. Science Advances. 9(1), eabn9793.

Inactive Disease in Lupus Patients Normalizes Ifnα and B-Cell Subsets

Bradford HF, Haljasmägi L, Menon M, McDonnell TCR, Särekannu K, Vanker M, Peterson P, Wincup C, Abida R, Gonzalez RF, Bondet V, Duffy D, Isenberg DA, Kisand K, Mauri C. (2023). Inactive disease in patients with lupus is linked to autoantibodies to type I interferons that normalize blood IFNα and B cell subsets. Cell Reports Medicine. 4 (1), 100894.

3D Model of Neural Deformation for Drug Discovery

Whitehouse C, Corbett N, Brownlees J. (2023). 3D models of neurodegeneration: implementation in drug discovery. Trends in Pharmacological Sciences. 44 (4), 208-221.

Cancer Organoid Co-culture Model Systems

Yuan J, Li X, Yu S. (2023). Cancer organoid co-culture model system: Novel approach to guide precision medicine. Frontiers in Immunology. 13: 1061388.

Overview of Human Disease Models

Loewa A, Feng JJ, Hedtrich S. (2023). Human disease models in drug development. Nature Reviews Bioengineering. 11: 1-15.

Animal Models of Diabetic Kidney Disease

Luo W, Tang S, Xiao X, Luo S, Yang Z, Huang  W, Tang S. (2023). Translation Animal Models of Diabetic Kidney Disease:  Biochemical and Histological Phenotypes, Advantages and Limitations. Diabetes,  Metabolic Syndrome, and Obesity. 16: 1297-1321.

Animal Models for COVID-19

Corleis B, Bastian M, Hoffmann D, Beer M, Dorhoi A. (2023). Animal models for COVID-19 and tuberculosis. Frontiers in Immunology. 14: 1223260.

Animal Models of Necrotizing Enterocolitis

Lopez CM, Sampah MES, Duess JW, Ishiyama A, Ahmad R, Sodhi CP, Hackam DJ. (2023). Models of necrotizing enterocolitis. Seminars In Perinatology. 47(1): 151695

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