The RPN1/MECOM DF FISH Probe Kit is intended to detect a fusion between the ribophorin I gene (RPN1) and the MDS1 and EVI1 complex locus gene (MECOM) using the fluorescence in situ hybridization (FISH) technique.
Acute myeloid leukemia (AML) with inv(3)(q21;q26.2) or t(3;3) (q21;q26.2) represents 1 to 2% of all AML. It has an aggressive disorder course with short survival and poor response to chemotherapy. These abnormalities may also be found in a similar percentage of myelodysplastic syndromes (MDS). Due to the subtle appearance of this rearrangement, particularly inv(3), conventional cytogenetic chromosome analysis may miss these abnormalities.
This probe identifies rearrangements between the RPN1 gene and the MECOM locus by detecting the fusion of the Locus Specific Identifier RPN1 Green and MECOM Red probe signals resulting from chromosomal rearrangement between the hybridization targets of the 2 probes.
For Research Use Only. Not for use in diagnostic procedures.
Store at minus 20 centigrade
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.