Retinoblastoma is a cancer of immature retina cells which occurs in infants and small children. RB1, a tumour suppressor gene may form complexes with oncoproteins and block their tumourigenic activity. The RB1 gene also plays a role in secondary tumours arising together with retinoblastoma, such as osteosarcoma and some soft tissue sarcomas. RB1 may also be missing as a result of a progressional tumourigenic event in some leukaemias, as well as in some breast, lung, bladder, oesophagus and prostate cancers.
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