The RARA Break Probe is intended to detect chromosomal rearrangements involving the RARA gene region at chromosome 17q21 using the fluorescence in situ hybridization (FISH) technique.
Acute promyelocytic leukemia (APL) is associated with chromosomal rearrangements involving the retinoic acid receptor α (RARA) gene on chromosome 17q21 and variable partner genes. In the vast majorityof APL cases, the RARA gene fuses with the promyelocytic leukemia gene (PML) located on chromosome 15q22 resulting in a t(15;17) translocation. RARA fusions with promyelocytic leukemia zinc finger (PLZF, 11q13), nucleophosmin (NPM, 5q35), nuclear mitotic apparatus (NuMA,11q23), signal transducer and activator of transcription 5b (STAT5B, 17q21), and PRKAR1A (protein kinase, cAMP-dependent, regulatory, type I, alpha, 17q23-q24) genes are also described. The RARA Break Apart Probe Kit has been used in several studies to detect chromosome 17q21 rearrangements involving the RARA gene.
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