The MET Probe Kit is based on the ability of MET locus-specific identifier (LSI) probe to identify copy number changes of 7q31.2 chromosomal locus, using a FISH test.
MET is a Receptor Tyrosine Kinase. It binds to the ligand, Hepatocyte Growth Factor (HGF). The MET pathway regulates many cellular responses including cell proliferation, survival, motility, invasion and morphogenesis. This pathway is one of the most frequently dysregulated pathways in human cancer for both solid tumors and hematological malignancies including gastric, head and neck, liver, ovarian, non-small cell lung (NSCL) and thyroid cancers, as well as in metastases of some of these cancers.
MET has been shown to be frequently overexpressed or amplified in many cancers, including brain, colorectal, gastric, lung, head and neck and stomach cancers.
For Research Use Only. Not for use in diagnostic procedures.
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