EWSR1 Break Probe

Specification
Recommended Products

Cat.No.

FONC-048

Description

Ewing's sarcoma is the second most frequent primary bone cancer in teenagers below 20 years of age. It is characterised mostly by translocation between the two genes EWSR1 (Ewing's Sarcoma Region 1) and FLI1 (Friend Leukaemia virus Integration 1) in the t(11;22)(q24;q12) translocation found in 85% of such tumours. EWSR1 is also involved in translocations in desmoplasmic small round cell tumour, a subset of angiomatoid fibrous histocytomas, and possibly in myxoid liposarcoma. The EWSR1 breakapart probe can also be used to distinguish rare soft tissue sarcoma and FISH has been shown to be a more sensitive and reliable method than RT-PCR for the detection of EWS in solid tissues.
The EWSR1 (22q12) Break Probe is optimized to detect translocations involving the EWSR1 gene region at 22q12 in a dual-color, split assay on metaphase/interphase spreads and paraffin embedded tissue sections.

Size

10 Tests

Label

Red/Green

Locus

22q12

Specificity

Human

Usage

For Research Use Only. Not for use in diagnostic procedures.

Storage

Store at minus 20 centigrade

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

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