The D20S108 fluorescence in situ hybridization (FISH) probe is intended to detect deletions of D20S108 probe target locus on 20q12. Cytogenetic analysis of del(20q) revealed that the deletion is variable in size, with a commonly deleted region (CDR) spanning 20q11.2 to q12. Within the commonly deleted segment lies the SRC oncogene and possibly other tumor suppressor genes. The CDR is defined as a 2.7 Mb segment in MPD and a 2.6 Mb segment in AML/MDS, with an overlapping region of 1.7 Mb.
Among MDS, MPD and MDS/MPD groups, Douet-Guilbert et al identified one commonly deleted region in all 38 investigated samples using FISH.
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