Chromosomal abnormalities on chromosome 13q occur in 16 - 40% of multiple myeloma cases and are associated with poor prognosis. Deletions affecting the 13q14 band are also the most frequent genetic abnormalities of B-cell Chronic Lymphocytic Leukaemia. Two non-coding RNA genes, DLEU1 and DLEU2 and the genetic marker D13S319 span the pathogenic critical region 13q14.3. DLEU1 is considered to be the most likely CLL-associated candidate tumour suppressor gene within the 13q14 region. Subsequently the locus D13S319, located between the RB1 gene and D13S25 and within the DLEU1 locus, was found to be deleted in 45% of CLL cases. The D13S319 deletion probe covers the marker and the centromeric end of the DLEU1 locus.
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