The CSF1R and D5S23, D5S721 fluorescence in situ hybridization (FISH) probes are intended to detect loss of the CSF1R probe target in the chromosome 5q33-q34 region.
Commonly deleted regions (CDRs) have been defined on chromosome 5q for myeloid malignancies by FISH and other techniques. A 1.5 Mb CDR containing the CSF1R gene has been established for the 5q- syndrome, a specific type of myelodysplastic syndrome. The loss of the hybridization signal from one copy of the LSI CSF1R probe target may be used to establish a deletion within the 5q- syndrome CDR. The Vysis LSI CSF1R/D5S23, D5S721 Dual Color Probe has been used in several studies to determine deletion of the LSI CSF1R probe target.
For Research Use Only. Not for use in diagnostic procedures.
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