The CCND1 Dual Color Break Apart Rearrangement FISH probe is intended to detect chromosomal rearrangements involving the Cyclin D1 (CCND1) gene region at chromosome 11q13.
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma and is commonly characterized by over-expression of CCND1 resulting from the t(11;14)(q13;q32) translocation. Over-expression of CCND1, which can result from chromosomal anomalies such as translocations or gain of the involved area, have been found to occur in multiple myeloma (MM) and MCL. The CCND1 Dual Color Break Apart Rearrangement Probe has been used to help identify rearrangement in the CCND1 breakpoint region in MCL.
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