BCR/ABL Translocation, Dual Fusion Probe

FHPC-020

The presence of the Philadelphia chromosome, produced as a result of the Philadelphia translocation t(9;22)(q34;q11), has important detective implications in a number of Haematological disorders. The abnormality is characteristic of CML (found in around 90% of cases) but represents a significant abnormality in 30% of adult and 2 to 10% of childhood ALL cases. This rearrangement is also seen in rare cases of AML. The stereotypic translocation fuses the ABL1 proto-oncogene to the BCR gene, giving rise to the BCR/ABL1 fusion gene, which encodes for tyrosine kinase.

5 Tests, 10 Tests

Red/Green

Human

9q34/22q11

For Research Use Only. Not for use in diagnostic procedures.

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