The BCL2 (18q21) Break probe is optimized to detect translocations involving the BCL2 gene region at 18q21 in a dual-color, split assay.
The B-cell CLL/Lymphoma 2 (BCL2) gene located at 18q21.33 encodes for a large protein family that regulate and contribute to programmed cell death or apoptosis by controlling the mitochondrial membrane permeability. Translocations of the BCL2 gene result in constant expression of the BCL2 protein. The t(14;18) is observed in 70-95% of Follicular Lymphoma (FL) cases and 20-30% of Diffuse Large B-cell Lymphoma (DLBCL). Presence of the t(14;18) translocation in DLBCL is a predictor of reduced overall and disorder free survival.
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