AURKA Probe

FONC-019

AURKA Probe Kit is designed to detect the copy number of Aurora Kinase A (AURKA) locus localized in chromosome 20 at the 20q13.2 band via fluorescence in situ hybridization (FISH) in human urine specimens.
This FISH assay is based on the ability of the Aurora Kinase A Locus-Specific Identifier (LSI) probe to identify copy number changes of the 20q13.2 chromosomal locus using a FISH test. Experimental data suggest that inappropriately high or low levels of Aurora Kinase activity are linked to genetic instability1 and that a high level of expression of Aurora Kinase A is often associated with amplification of the region of chromosome 20 encoding AURKA, indicating that deregulated expression of at least one gene in the amplified region provides a survival/proliferation advantage to a tumor cell and is therefore linked directly to neoplasia.2 Over-expression of the Aurora Kinase A gene has also been shown to be associated with aneuploidy, chromosome instability and promotion of tumorigenic transformation and progression in mammalian cells and in several human tumors, including urothelial carcinoma.3,4 AURKA amplification has been demonstrated in breast, colon, brain, bladder, head/neck and endometrium cancers, and its expression in tumors is often associated with genetic instability.2 FISH data on voided urine samples with bladder cancer indicate that amplification of AURKA is frequent in bladder cancer and can be detected in urothelialcells.5,6 Further, amplification of chromosome 20q has been associated with aggressive variants of several common malignancies, including bladder cancer.

20 Tests

Red/Green

Human

20q13.2

For Research Use Only. Not for use in diagnostic procedures.

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