KYSE170

Cat.No.: CSC-C6805J

Species: Homo sapiens (Human)

Source: Esophagus

Morphology: Epithelial-Like

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Cat.No.

CSC-C6805J

Description

Human squamous cell carcinoma cell line established from esophageal cancer.

Species

Homo sapiens (Human)

Source

Esophagus

Recommended Medium

Ham's F12 medium and RPMI-1640 (1:1) + 2% FBS

Morphology

Epithelial-Like

Disease

Esophageal Squamous Cell Carcinoma

Storage

Liuqid Nitrogen, -180°C.

Shipping

Dry Ice.

Synonyms

KYSE-170; KYSE 170; KYSE0170

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

The KYSE-170 cell line is a human esophageal squamous cell carcinoma (ESCC) model established from a primary tumor resected from a Japanese patient. As a primary tumor-derived line, KYSE-170 retains genetic and phenotypic features reflective of the clinical disease, making it a reliable and frequently utilized system in both basic and translational ESCC research.

KYSE-170 cells exhibit typical epithelial morphology and demonstrate aggressive growth properties consistent with carcinoma cells. Genomically, it is characterized by mutations commonly found in ESCC, including alterations in the TP53 tumor suppressor gene and CDKN2A (p16), contributing to dysregulated cell cycle progression and genomic instability. The line is tumorigenic in immunocompromised mice, forming solid tumors suitable for preclinical therapeutic studies. KYSE-170 has been extensively profiled at the genomic, transcriptomic, and proteomic levels, positioning it as one of the most well-annotated ESCC models available.

Low Levels of Tumor Suppressor miR-3619 Contribute to Malignant Outcomes and A Target for Nucleic Acid Therapy in Esophageal Cancer

Recent studies indicate that reduced levels of certain tumor-suppressing microRNAs (miRNAs) circulating in the blood are linked to tumor progression and poor prognosis across various types of malignancies. Identified from a comprehensive analysis of the NCBI and miRNA databases, we tested tumor suppressor miR-3619-5p in esophageal squamous cell carcinoma (ESCC). Both test-scale and large-scale analyses demonstrated that plasma levels of miR-3619-5p were markedly lower in ESCC patients than in healthy volunteers. Lower plasma levels of miR-3619-5p showed a strong association with advanced pathological stages and were recognized as an independent prognostic marker. Overexpression of miR-3619-5p in ESCC cells inhibited cell proliferation, migration and invasion through the direct suppression of novel target protein, proviral insertion site in Moloney murine leukemia virus 1 (PIM1). PIM1 is overexpressed in various solid and hematological cancers including ESCC, and has proven to be a promising target of inhibitors in recent clinical trials.