P-selectin also called Platelet Alpha-Granule Membrane Protein, CD62, or Granulocyte Membrane Protein GRMP belongs to a family of divalent cation-dependent carbohydrate- binding glycoproteins or adhesion molecules. P-selectin is expressed transiently on the surface of activated platelets and endothelial cells. P-selectin is a 140 kDa protein which is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Secreted P-selectin is thought to play a key role in the adhesion of platelets to monocytes and neutrophils during an inflammatory response. P-selectin is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Levels of P-selectin may be elevated in a number of pathological conditions.|Human recombinant P-selectin produced in E. coli contains 566 amino acids 197-761 which are fused to an amino-terminal hexa-histidine tag.
Human SELP expressed in E.coli
CAT# CSC-CTK0652-10 (10 μg); CAT# CSC-CTK0652-50 (50 μg)
Greater than 95% as determined by SDS-PAGE analysis.
Sterile-filtered, liquid formulation. P-selectin is supplied in 50% glycerol.
Please centrifuge product briefly before opening vial. The protein solution can be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
For long-term storage, protein solution should be stored at -20°C. Avoid repeated freeze / thaw cycles.
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