Pericytes
Pericytes are vascular mural cells embedded in the basement membrane of blood microvessels. They extend their processes along capillaries, pre-capillary arterioles and post-capillary venules. Pericytes regulate blood-brain barrier (BBB) permeability, angiogenesis, clearance, cerebral blood flow (CBF), neuroinflammation and stem cell activity.
BBB permeability
Pericytes control the expression of endothelial BBB tight and adherens junction proteins, the alignment of tight junction proteins and bulk-flow transcytosis of fluid-filled vesicles across the BBB. Molecular pathways between pericytes and endothelial cells can be manipulated to open the BBB 'on demand' for neuropharmaceutical delivery and/or to reverse BBB disruption in neurological diseases.
Angiogenesis
Pericytes regulate angiogenesis, microvascular stability and angioarchitecture during CNS development and vascular remodeling.
Clearance
Pericytes can also act as perivascular tissue macrophages to clear tissue debris and foreign proteins injected systemically and/or locally into the CNS and participate in clearance of Alzheimer's amyloid-β toxin, as shown in a mouse Alzheimer's disease model.
CBF
The mammalian brain has evolved a regional control mechanism for CBF, known as neurovascular coupling, which ensures a rapid increase in the amount of CBF directed to active neurons. Neurovascular coupling is controlled by cells within the neurovascular unit, including pericytes. Pericytes can actively relax or contract to change CBF in response to localized changes in neuronal activity.
Neuroinflammation
Pericytes are able to recruit immune cells and enable their extravasation into the brain. In transgenic pericyte-deficient mice, there is reduced leukocyte trafficking across the microvasculature, suggesting a role for pericytes in leukocyte recruitment to the brain.
Stem cell activity
In vitro studies have shown that cultured pericytes have pluripotent stem cell potential. Furthermore, mouse primary pericytes isolated from brain following ischemic stroke exhibit pluripotential stem cell activity and differentiate into neural and vascular lineage cells. The exact mediators that control pericyte differentiation are still under investigation, but pericyte pluripotency can be used as a target for therapeutic intervention for a number of diseases.
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Description: Human Brain Vascular Pericytes (HBVP) from Creative Bioarray are isolated from human brain tissue. ...
Description: Human Placental Microvascular Pericytes (HPMPs) are isolated from normal human placental tissue. ...
Description: Primary Human Retinal Pericyte Cells (HRPEpiC) are isolated from human retina. HRPEpiC are ...
Description: Primary Human Brain Microvascular Pericyte Cells were initiated by elutriation from normal human ...
Description: Human Retinal Pericytes are isolated from human healthy retina. HRP are cryopreserved at passage ...
Description: Lung Microvascular Pericytes are distributed in the microvasculature of lung tissue and are ...
Description: Cerebrovascular pericytes are distributed in the microvasculature of brain tissue and are a key ...
Description: The kidney is a part of the urinary system, responsible for filtering impurities in the blood, ...
Description: The kidney is a part of the urinary system, responsible for filtering impurities in the blood, ...
Description: Pulmonary Microvascular Pericytes are distributed in the microvasculature of lung tissue and are ...
Description: Cerebrovascular pericytes are distributed in the microvasculature of brain tissue and are a key ...
Description: Cerebrovascular pericytes are distributed in the microvasculature of brain tissue and are a key ...
Description: Pulmonary microvascular pericytes are distributed in the microvasculature of lung tissue and are ...
Description: RFP Expressing Human Brain Microvascular Pericytes (RFP-HBMPs) provided by Creative Bioarray are ...
Description: GFP Expressing Human Retinal Microvascular Pericytes (GPF-HRMPs) provided by Creative Bioarray are ...
Description: RFP Expressing Human Retinal Microvascular Pericytes (RFP-HRMPs) provided by Creative Bioarray are ...
Description: GFP Expressing Human Placental Microvascular Pericytes (GFP-HPlMVPCs) provided by Creative Bioarray ...
Description: GFP Expressing Human Brain Microvascular Pericytes (GFP-HBMVPs) provided by Creative Bioarray are ...