T Cells

T lymphocytes originate from bone marrow progenitors that migrate to the thymus for maturation, selection, and subsequent export to the periphery. Peripheral T cells comprise different subsets including naïve T cells, which have the ability to respond to new antigens, memory T cells that derived from previous antigen activation and maintain long-term immunity, and regulatory T (Treg) cells which enable immune responses in check.

The role of T cells in immune responses and at different life stages is not uniform throughout the body. T cells are found in nearly every organ and tissue in the body including primary and secondary lymphoid tissue, mucosal and barrier sites, exocrine organs, fat, and even the brain and central nervous system (CNS). In terms of numbers, the majority of T cells in the human body are likely to be found in lymphoid tissues and large numbers also present in mucosal sites and skin, accounting for 2-3% of the total T cell complement in human peripheral blood.

T cells are essential in the immune response against tumor cells, in addition, immunotherapies such as immune checkpoint blockade, adoptive T cell therapy, and CAR-T cells rely on these cells to trigger the elimination of tumor cells.

Our purified adaptive immune T cells include CD3+, CD4+, and CD8+ subsets, as well as a dedicated collection of antigen-specific T cells that respond to peptides derived from bacteria, viruses, normal tissues, and tumor cells.

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