IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells and has been shown to stimulate release of TNF-alpha and IL-1beta from cells of the monocyte lineage. Recombinant human IL-17B is a 36.6 kDa disulfide-linked homodimer of two 161 amino acid polypeptide chains.
Human IL17B expressed in E.coli
CAT# CSC-CTK0260-10 (10 μg); CAT# CSC-CTK0260-50 (50 μg)
Greater than 98% as determined by SDS-PAGE and HPLC analysis.
Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10-100 ng. Please note: Results may vary with PBMC donors.
Less than 1 EU/μg.
Lyophilized (freeze-dried), sterile powder. Lyophilized with no additives.
Please centrifuge product briefly before opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0,1 - 1,0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted rHu IL-17B should be used immediately or stored long-term in undiluted working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
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