CD68 is a 110 kDa transmembrane (Type I) glycoprotein consisting of a polypeptide of 37,408 kDa (354 amino acids) which corresponding cDNA sequence is highly expressed by human monocytes and tissue macrophages. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell- pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes, lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.
Human CD68 expressed in E.coli
CAT# CSC-CTK0311-2 2 μg; CAT# CSC-CTK0311-10 (10 μg)
Greater than 90% as determined by SDS-PAGE and HPLC analysis.
Less than 1 EU/μg.
Sterile-filtered, clear solution. Recombinant prote in at 100 μg/ml in 50 mM Tris-acetate (pH 7.5), 1 mM EDTA and 20% glycerol without BSA and sodium azi de.
Storage & Stability
Please Note: Always centrifuge product briefly before opening vial. Store vial at –20°C to –80°C. When stored at the recommended temperature, this protein is stable for 12 months. Avoid repeated freeze-thaw cycles
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