Immortalized Murine Cells
Murine cells show frequent spontaneous immortalization in contrast to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway.
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Description: In aldosterone-sensitive distal nephron (ASDN), mineralocorticoid receptor (MR) and glucocorticoid ...
Description: As messengers bridging the innate and adaptive immune system, the conventional tissue-resident DC ...
Description: Enteroglial cells (EGCs) have a key role in the inflammatory response in the enteric nervous system ...
Description: Lutropin/choriogonadotropin (LH/CG) receptor, a receptor uniquely expressed in ovarian granulosa ...
Description: The Immortalized Mouse Astrocytes- SV40 T (IMA 2.1) is a suitable cell line for studies in ...
Description: Clara cells play a role in the maintenance of normal bronchiolar epithelium by secreting Clara Cell ...
Description: Homeostasis of the central nervous system (CNS) is maintained by the blood brain barrier (BBB) and ...
Description: The Immortalized Mouse Mammary Epithelial Cells (iMMEC) is derived by co-expression of adenovirus ...
Description: The Immortalized Mouse Prostate Epithelial Cells (iMPEC, clone7) is derived by co-expression of ...
Description: YAMC is a conditionally immortalized mouse colon epithelial cell line isolated from the mouse ...
Description: The Immortalized Ovarian Surface Epithelial Cells (iMOSEC) is derived by co-expression of ...
Description: The mammalian cerebellum is indispensable in the coordination of voluntary movement (i.e. balance ...
Description: The Immortalized Baby Mouse Kidney Epithelial Cells (iBMK, Clone W2) is derived by co-expression of ...
Description: ImSt is a conditionally immortalized mouse stomach epithelial cell line isolated from the mouse ...
Description: IMPE is a conditionally immortalized mouse pancreas epithelial cell line isolated from the mouse ...
Description: MSIE is a conditionally immortalized mouse small intestine epithelial cell line isolated from the ...
Description: The epididymal epithelium plays an important role in male fertility by supporting sperm motility, ...