Immortalized Murine Cells
Murine cells show frequent spontaneous immortalization in contrast to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway.
Creative Bioarray can provide you immortalized murine cell lines with an integrated platform for meeting the needs for virtually any relevant research project.
Description: Alveolar macrophages were isolated from the brochoalveolar lavage fluid of ...
Description: The Immortalized Mouse Wildtype M4+/+Epidermal Keratinocyte Cells were derived from primary ...
Description: The Immortalized Mouse Neuronal Cells (M4b) were derived from the spinal cord of a fetal mouse ...
Description: The Immortalized Immortalized Mouse EGFR Mutant M3-/-Epidermal Keratinocytes were derived from ...
Description: The Immortalized Rat Retinal Capillary Endothelial Cells are immortalized with SV40 antigen. These ...
Description: The Immortalized Mouse EGFR Mutant M4-/-Epidermal Keratinocytes were derived from primary ...
Description: The Immortalized Bcl-x Mouse Embryonic Fibroblasts - SV40T were derived from primary embryonic ...
Description: Immortalized Mouse Hepatic Stellate Cells-SV40 were derived from WT mouse via enzymatic digestion ...
Description: The Immortalized Mouse Atrioventricular Cushion Mesenchymal Cells (tsA58-AVM) were derived from ...
Description: The Immortalized Trisomy 16 Mouse Neuronal Cells (MTh) were derived from the spinal cord of a ...
Description: The Immortalized Mouse WildType Aortic Endothelial Cells (iMAEC-WT) were derived from primary mouse ...
Description: The Immortalized Mouse Hepatic Stellate Cells were derived from MyD88-/-mouse via enzymatic ...