The PML/RARA Dual Color Single Fusion Probe is intended to detect the t(15;17)(q22;q21.1) reciprocal translocation involving the PML and RARA gene regions.
The vast majority of cases of acute promyelocytic leukemia (APL) have a t(15;17)(q22;q21.1) translocation which fuses the promyelocytic leukemia gene (PML) on chromosome 15q22-q24 to the retinoic acid receptor alpha gene. The PML/RARA fusion is associated with a good response to all-trans retinoic acid therapy.
This Probe was used in a study of 260 acute myeloid leukemia sampless and detected 11 positive samples. In the same study, conventional banding analysis resulted in only 7 positive results due to cytogenetic failure and one case of a cryptic translocation.
For Research Use Only. Not for use in diagnostic procedures.
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