IGH/MYEOV Translocation, Dual Fusion Probe

FHPC-071

The most common translocation in Multiple Myeloma is the t(11;14)(q13;q32) which accounts for 15-20% of cases that were identified by FISH. These translocations lead to overexpression of Cyclin D1 in about 25% of cases. The breakpoints in Multiple Myeloma cases are dispersed within a 360Kb region between CCND1 and MYEOV genes. MYEOV is a putative oncogene and it's thought to be activated in the translocation by it becoming closely associated with IGH enhancers.

5 Tests, 10 Tests

Red/Green

Human

11q13/14q32

For Research Use Only. Not for use in diagnostic procedures.

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