Description
The most common translocation in Multiple Myeloma is the t(11;14)(q13;q32) which accounts for 15-20% of cases that were identified by FISH. These translocations lead to overexpression of Cyclin D1 in about 25% of cases. The breakpoints in Multiple Myeloma cases are dispersed within a 360Kb region between CCND1 and MYEOV genes. MYEOV is a putative oncogene and it's thought to be activated in the translocation by it becoming closely associated with IGH enhancers.
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade
Citation Guidance
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