FUS Break Apart FISH Probe Kit

Specification
Recommended Products

Cat.No.

FONC-059

Description

Chromosomal rearrangements involving the FUS gene located on chromosome 16p11 have been observed in many tumor types including several soft tissue sarcomas (STS). Different types of STS are characterized by specific chromosomal translocations including t(12;16)(q13;p11) FUS-DDIT3 (Myxoid liposarcoma), t(16;21)(p11;q22) FUS-ERG (Acute myeloid leukemia), t(12;16)(q13;p11) FUS-ATF1 (Angiomatoid-fibrous histiocytoma) and t(7;16)(q32-34;p11) FUS-CREB3L2 (Low grade fibromyxoid sarcoma). The resulting chimeric fusion proteins are mainly transactivators exerting deregulation of differentiation control on the tumor-target cell.1,2 Hybridization with the FUS (16p11) Dual Color, Break Apart Rearrangement Probe will identify a chromosomal rearrangement in the FUS gene region but not a specific gene-fusion partner. FUS FISH-probes were successfully used to confirm diagnosis of different sarcomas as demonstrated by several studies. This Probe detected rearrangement of the FUS gene in 7/10 formalin-fixed, paraffin-embedded tissues from low-grade fibromyxoid sarcomas. In another study the FUS Dual Color, Break Apart Rearrangement Probe was used to detect rearrangement of the FUS gene in a rare case of Ewing bone sarcoma bearing a variant chromosomal translocation t(2;16)(q35;p11) resulting in a FUS-FEV fusion gene.

Size

20 Tests

Label

Red/Green

Locus

16p11

Specificity

Human

Usage

For Research Use Only. Not for use in diagnostic procedures.

Storage

Store at minus 20 centigrade

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

FONC-001

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19q13/p53 (17p13) Probe

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