EWSR2 Break Probe

FONC-051

Chromosome rearrangements involving the EWSR1 (Ewing sarcoma breakpoint region 1) have been observed in several types of tumors1. Approximately 90% of the translocations involving the EWSR1 gene result in the t(11;22) (q24;q12), which juxtaposes the EWSR1 with the FLI1 (Friend leukemia virus integration 1) gene on chromosome 11q241-2. The resulting fusion produces chimeric transcripts and proteins that consist of the N-terminus of EWSR1 and the C-terminal portion of FLI12. Hybridization with the LSI EWSR1 (22q12) Break Apart Rearrangement Probe will identify chromosomal rearrangement in the EWSR1 gene region, but not a specific gene-fusion partner. The probe will also identify aneuploidy of chromosome 22. This Probe has been used in several studies to detect EWSR1 gene rearrangements. In a study set consisting of 67 archival round cell tumors, including 27 EWS/PNETs (Ewing sarcoma/primitive neurodectodermal tumor). Sensitivity and specificity were significantly higher compared to reverse transcriptase-polymerase chain reaction in formalin-fixed paraffin-embedded tissue.

20 Tests

Red/Green

Human

22q12

For Research Use Only. Not for use in diagnostic procedures.

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