EWSR2 Break Probe

Specification
Recommended Products

Cat.No.

FONC-051

Description

Chromosome rearrangements involving the EWSR1 (Ewing sarcoma breakpoint region 1) have been observed in several types of tumors1. Approximately 90% of the translocations involving the EWSR1 gene result in the t(11;22) (q24;q12), which juxtaposes the EWSR1 with the FLI1 (Friend leukemia virus integration 1) gene on chromosome 11q241-2. The resulting fusion produces chimeric transcripts and proteins that consist of the N-terminus of EWSR1 and the C-terminal portion of FLI12. Hybridization with the LSI EWSR1 (22q12) Break Apart Rearrangement Probe will identify chromosomal rearrangement in the EWSR1 gene region, but not a specific gene-fusion partner. The probe will also identify aneuploidy of chromosome 22. This Probe has been used in several studies to detect EWSR1 gene rearrangements. In a study set consisting of 67 archival round cell tumors, including 27 EWS/PNETs (Ewing sarcoma/primitive neurodectodermal tumor). Sensitivity and specificity were significantly higher compared to reverse transcriptase-polymerase chain reaction in formalin-fixed paraffin-embedded tissue.

Size

20 Tests

Label

Red/Green

Locus

22q12

Specificity

Human

Usage

For Research Use Only. Not for use in diagnostic procedures.

Storage

Store at minus 20 centigrade

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

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