ADME, an abbreviation for absorption, distribution, metabolism, and elimination, describes the disposition of drug candidates within an organism. ADME determine the drug levels and kinetics within a body, and hence influence the performance and bioactivity of the compound as a drug. Therefore, ADME assessment of candidate compounds is a crucial step in drug development before going to clinical trials.
Creative Bioarray offers standard, predictive and comprehensive cell-based ADME tests by utilization of the state-of-the-art techniques, industry leading products and equipment. We are dedicated to helping drug developers reduce cost and time-to-market by providing reliable and fast data. The service groups at Creative Bioarray are highly skilled in absorption, transport metabolism studies, which enable us to develop a wide range of ADME tests to meet the customers’ special needs.
Understanding drug metabolism is essential for evaluating efficacy and safety, as well as potential drug-drug interaction, in the drug discovery process.
The liver plays a key role in drug metabolism in the body, which is mainly mediated by hepatic Cytochrome P450 (CYPs). Drug metabolism stability measures the ability of the body or an organ to clear the compound, which is a key factor in determining drug administration as well as drug-drug interaction studies.
As a specialized provider for drug metabolism services, Creative Bioarray offers a series of human hepatocytes based assays to support you in the development of drugs.
• Metabolism stability assessment
• Metabolite identification
• Metabolite profiling
Creative Bioarray is dedicated to delivering high-quality and consistent data with cost-efficiency to the customers.