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2D cell cultures have been widely used in the cell-based drug discovery tests and have served as a simple and cost-effective tool to quickly screening drug candidates instead of high-cost in vivo animal tests. However, due to its limitations of not being able to realistically mimic in vivo cell behaviors, 2D cell culture-based tests are unable to rule out compounds that lack clinical efficacy or cause unacceptable toxicity, and consequently lead to more drug failure in the following more expensive phases of drug. Meanwhile, 3D cell cultures have been shown to exhibit more in-vivo-like behaviors and responses compared to 2D cultures, with cell-cell and cell-extracellular matrix (ECM) interactions as well as nutrient and drug spatial gradient that resemble in vivo environments. Drug tests using 3D cell cultures are capable of providing more reliable and applicable results, enabling better estimate of in vivo responses and lower overall cost by reducing future drug failure incidents.
In response to the increasing need for tests using 3D cell culture systems in the drug discovery field, Creative Bioarray has developed a panel of 3D-based drug discovery services to provide more predictable data to in vivo tests. Our well-developed 3D-based drug discovery services include:
Creative Bioarray 3D-based drug discovery service advantages
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